CLNK
Cytokine-Dependent Hematopoietic Cell Linker
Gene Information Card
| Symbol | CLNK |
|---|---|
| Full Name | Cytokine-Dependent Hematopoietic Cell Linker |
| Gene Type | protein-coding |
| Chromosomal Location | 4p16.3 |
| NCBI Gene ID | 116449 ncbi.nlm.nih.gov/gene/116449 |
| Ensembl ID | ENSG00000109685 |
| UniProt ID | Q7Z7G1 |
| OMIM ID | 611228 |
| HGNC ID | 17416 |
| Aliases | MIST |
Description
CLNK encodes a cytoplasmic adapter protein primarily expressed in hematopoietic cells. It functions downstream of cytokine receptors and immunoreceptors, linking receptor activation to intracellular signaling pathways such as MAPK and PI3K/AKT. CLNK is involved in mast cell, T cell, and natural killer cell activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CLNK variants may alter mast cell signaling, contributing to airway hyperresponsiveness | ClinVar, OMIM |
| Allergic rhinitis | Polymorphisms in CLNK associated with increased IgE levels | NCBI Gene, OMIM |
| Hematologic malignancies | Dysregulation of CLNK expression in leukemia cell lines | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Bone marrow | 8.3 | Medium |
| Lymph node | 6.7 | Low |
| Whole blood | 4.2 | Low |
| Lung | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.0 | Leukemia cell line |
| HL-60 | 10.2 | Promyeloblast |
| Jurkat | 8.5 | T-cell leukemia |
| THP-1 | 6.3 | Monocytic leukemia |
| HEK 293 | 0.5 | Non-hematopoietic control |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Alters SH2 domain binding affinity |
| c.245G>A (p.Arg82Gln) | Missense | <0.01% | Unknown functional impact |
| c.523_524insA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• T cell receptor signaling pathway (KEGG: hsa04660)
Protein Summary
CLNK (MIST) is a 50 kDa cytoplasmic adapter protein containing an SH2 domain and multiple tyrosine phosphorylation sites. It is expressed in hematopoietic cells and mediates signals from cytokine receptors and immunoreceptors. Upon activation, CLNK recruits downstream effectors such as GRB2 and PLCG1, modulating calcium flux and MAPK activation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLNK Knockout HEK293 Cell Line | EDJ-KQ7572 | Human | 116449 | Details Get a Quote |
| CLNK Knockout HeLa Cell Line | EDJ-KQ57990 | Human | 116449 | Details Get a Quote |
| CLNK Knockout A-549 Cell Line | EDJ-KQ66476 | Human | 116449 | Details Get a Quote |
| CLNK Knockout HCT 116 Cell Line | EDJ-KQ74899 | Human | 116449 | Details Get a Quote |
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