CLMN Gene: Calmodulin-Like Protein
Comprehensive genomic and proteomic analysis of CLMN, a calmodulin-related gene with emerging roles in cellular signaling and disease.
Gene Information Card
| Symbol | CLMN |
|---|---|
| Full Name | calmodulin-like protein |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 79789 ncbi.nlm.nih.gov/gene/79789 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q96JQ2 |
| OMIM ID | 611143 |
| HGNC ID | 24005 |
| Aliases | FLJ10769, MGC138290, MGC138291 |
Description
CLMN (calmodulin-like protein) is a protein-coding gene located on chromosome 14q32.13. It encodes a protein with similarity to calmodulin, a key calcium-binding messenger protein. CLMN is involved in cellular signaling and has been implicated in various cancers and developmental processes. The gene is conserved across species and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression and potential role in cell proliferation | COSMIC, NCBI Gene |
| Breast cancer | Differential expression observed in tumor vs normal tissue | COSMIC, NCBI Gene |
| Lung cancer | Mutations and expression changes reported | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Colon | 5.8 | Low |
| Breast | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 7.9 | Cervical cancer cell line |
| A549 | 6.5 | Lung cancer cell line |
| MCF7 | 5.2 | Breast cancer cell line |
| HCT116 | 4.8 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A | Missense | <0.1% | Unknown |
| c.567C>T | Nonsense | <0.01% | Predicted loss of function |
| c.890_891insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to cause loss of function, potentially impairing calcium signaling.
Gain of Function (GOF)
No evidence of gain-of-function mutations in CLMN.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • calmodulin binding |
| • signal transduction | • cytoplasm |
| • nucleus |
Pathways
• Calcium signaling pathway
• Calmodulin-dependent signaling
Protein Summary
The CLMN protein is a 148-amino acid calmodulin-like protein with four EF-hand calcium-binding domains. It is localized in the cytoplasm and nucleus and is involved in calcium-dependent signal transduction. The protein shares structural homology with calmodulin but has distinct functional roles, including regulation of cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLMN Knockout HEK293 Cell Line | EDJ-KQ12949 | Human | 79789 | Details Get a Quote |
| CLMN Knockout A-549 Cell Line | EDJ-KQ42159 | Human | 79789 | Details Get a Quote |
| CLMN Knockout HCT 116 Cell Line | EDJ-KQ42160 | Human | 79789 | Details Get a Quote |
| CLMN Knockout HeLa Cell Line | EDJ-KQ57228 | Human | 79789 | Details Get a Quote |
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