CLK2: CDC Like Kinase 2
A dual-specificity kinase regulating alternative splicing and cell cycle progression
Gene Information Card
| Symbol | CLK2 |
|---|---|
| Full Name | CDC Like Kinase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q22 |
| NCBI Gene ID | 1196 ncbi.nlm.nih.gov/gene/1196 |
| Ensembl ID | ENSG00000117461 |
| UniProt ID | P49760 |
| OMIM ID | 602989 |
| HGNC ID | 2069 |
| Aliases | CLK2, CDC-like kinase 2, LAMMER kinase |
Description
CLK2 encodes a dual-specificity protein kinase that phosphorylates serine, threonine, and tyrosine residues. It regulates alternative splicing by phosphorylating SR proteins and plays a role in cell cycle control, apoptosis, and neurodevelopment. CLK2 is implicated in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression leads to altered splicing of oncogenes | COSMIC, literature |
| Colorectal cancer | CLK2 amplification promotes cell proliferation | COSMIC, literature |
| Neurodevelopmental disorders | Missense variants affect kinase activity | ClinVar, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.0 | High expression |
| HeLa | 9.5 | Moderate expression |
| MCF7 | 11.2 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Reduced kinase activity |
| c.1234A>G (p.Lys412Glu) | Missense | <0.01% | Altered substrate specificity |
| Amplification | Copy number gain | 5-10% in breast cancer | Increased expression |
Mutation functional classification
Loss of Function (LOF)
p.Arg349Trp reduces catalytic activity
Gain of Function (GOF)
Amplification leads to overexpression
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • protein tyrosine kinase activity |
| • ATP binding | • regulation of alternative mRNA splicing |
| • cell cycle | • apoptotic process |
Pathways
• Spliceosome
• mRNA Splicing - Major Pathway
• Signaling by Receptor Tyrosine Kinases
Protein Summary
CLK2 is a 499-amino acid dual-specificity kinase with an N-terminal kinase domain and a C-terminal RS domain. It phosphorylates SR splicing factors, modulating splice site selection. CLK2 also interacts with cyclins and regulates cell cycle progression. Its activity is controlled by autophosphorylation and cellular localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLK2 Knockout HEK293 Cell Line | EDJ-KQ1858 | Human | 1196 | Details Get a Quote |
| CLK2 Knockout A-549 Cell Line | EDJ-KQ23086 | Human | 1196 | Details Get a Quote |
| CLK2 Knockout HCT 116 Cell Line | EDJ-KQ23087 | Human | 1196 | Details Get a Quote |
| CLK2 Knockout HeLa Cell Line | EDJ-KQ23088 | Human | 1196 | Details Get a Quote |
