CLIP1 Gene - CAP-Gly Domain Containing Linker Protein 1
Essential regulator of microtubule dynamics and intracellular transport
Gene Information Card
| Symbol | CLIP1 |
|---|---|
| Full Name | CAP-Gly domain containing linker protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 6249 ncbi.nlm.nih.gov/gene/6249 |
| Ensembl ID | ENSG00000139173 |
| UniProt ID | P30622 |
| OMIM ID | 179838 |
| HGNC ID | 2062 |
| Aliases | CLIP-170, RSN, CYLN1 |
Description
CLIP1 encodes a member of the CAP-Gly domain-containing linker protein family. The protein, also known as CLIP-170, links endocytic vesicles to microtubules and regulates microtubule dynamics by promoting plus-end growth and stabilizing microtubule ends. It is involved in cell migration, intracellular transport, and mitotic spindle organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | CLIP1 overexpression promotes tumor cell migration and invasion via enhanced microtubule dynamics | PMID: 25605247 |
| Lung cancer | CLIP1 upregulation correlates with poor prognosis and increased metastatic potential | PMID: 29174920 |
| Neurodegenerative disorders | CLIP1 mutations impair axonal transport and microtubule stability, contributing to neuronal dysfunction | PMID: 30190465 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Colon | 15.2 | Medium |
| Liver | 6.1 | Low |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | High expression in cervical cancer cell line |
| A549 | 14.2 | Moderate expression in lung adenocarcinoma cells |
| HCT116 | 22.1 | High expression in colorectal carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | 0.02% | Altered microtubule binding affinity |
| c.567_569del (p.Lys189del) | In-frame deletion | 0.01% | Reduced protein stability |
| c.2101C>T (p.Arg701Trp) | Missense | 0.03% | Impaired vesicle transport |
Mutation functional classification
Loss of Function (LOF)
Mutations that reduce microtubule binding or protein stability lead to loss of function, impairing intracellular transport and cell division.
Gain of Function (GOF)
Overexpression or activating mutations enhance microtubule polymerization and cell motility, contributing to cancer metastasis.
Dominant Negative (DN)
Truncating mutations that retain dimerization but lack CAP-Gly domains can interfere with wild-type CLIP1 function.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • plus-end-directed microtubule motor activity |
| • microtubule cytoskeleton organization | • intracellular transport |
| • cell division |
Pathways
• Microtubule dynamics regulation
• Endocytosis
• Cell cycle
• mitotic
Protein Summary
CLIP1 (CLIP-170) is a 170 kDa cytoplasmic linker protein that binds to the plus ends of microtubules via its N-terminal CAP-Gly domains. It recruits endocytic vesicles and other cargo to microtubules, facilitates microtubule growth, and stabilizes the microtubule network. The protein contains a coiled-coil region for dimerization and a C-terminal zinc finger domain. CLIP1 is widely expressed, with highest levels in testis and brain, and its dysregulation is implicated in cancer and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLIP1 Knockout HEK293 Cell Line | EDJ-KQ1171 | Human | 6249 | Details Get a Quote |
| CLIP1 Knockout A-549 Cell Line | EDJ-KQ19082 | Human | 6249 | Details Get a Quote |
| CLIP1 Knockout HCT 116 Cell Line | EDJ-KQ20433 | Human | 6249 | Details Get a Quote |
| CLIP1 Knockout HeLa Cell Line | EDJ-KQ20434 | Human | 6249 | Details Get a Quote |
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