CLIC1: Chloride Intracellular Channel 1
A multifunctional chloride channel protein involved in cell cycle regulation, oxidative stress, and cancer progression.
Gene Information Card
| Symbol | CLIC1 |
|---|---|
| Full Name | Chloride Intracellular Channel 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.33 |
| NCBI Gene ID | 1192 ncbi.nlm.nih.gov/gene/1192 |
| Ensembl ID | ENSG00000113722 |
| UniProt ID | O00299 |
| OMIM ID | 602867 |
| HGNC ID | 2062 |
| Aliases | NCC27, CLIC1L |
Description
CLIC1 (Chloride Intracellular Channel 1) encodes a member of the chloride intracellular channel family of proteins. The protein functions as a chloride ion channel and is involved in cell cycle regulation, oxidative stress response, and cellular proliferation. It is widely expressed and has been implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression promotes cell proliferation and invasion | COSMIC, NCBI Gene |
| Gastric Cancer | Upregulation associated with tumor growth and metastasis | NCBI Gene, UniProt |
| Hepatocellular Carcinoma | Increased expression linked to poor prognosis | NCBI Gene |
| Alzheimer's Disease | Dysregulation of chloride homeostasis in neurons | UniProt, OMIM |
| Rheumatoid Arthritis | Involvement in synovial inflammation | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skeletal Muscle | 45.2 | High |
| Heart | 38.1 | High |
| Liver | 25.6 | Medium |
| Brain | 22.3 | Medium |
| Lung | 18.7 | Medium |
| Kidney | 15.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 32.5 | Cervical cancer cell line |
| A549 | 28.9 | Lung cancer cell line |
| MCF7 | 24.1 | Breast cancer cell line |
| HepG2 | 21.3 | Liver cancer cell line |
| K562 | 19.8 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T | Missense | 0.02% | p.Thr79Ile; potential functional impact |
| c.412G>A | Missense | 0.01% | p.Gly138Arg; rare variant |
| c.523A>G | Synonymous | 0.03% | p.Thr175Thr; no amino acid change |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CLIC1.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in proliferation.
Dominant Negative (DN)
Not described for CLIC1.
View complete mutation data：
Gene Ontology (GO)
| • Chloride channel activity | • Intracellular chloride channel activity |
| • Voltage-gated chloride channel activity | • Protein binding |
| • Cell cycle regulation | • Oxidative stress response |
Pathways
• Chloride channel complex
• Ion transport
• Cell cycle
• Apoptosis
Protein Summary
CLIC1 is a 241-amino acid protein that exists in both soluble and membrane-associated forms. It functions as a chloride ion channel, regulating ion homeostasis, cell volume, and membrane potential. The protein is involved in cell cycle progression, particularly at the G2/M checkpoint, and responds to oxidative stress by translocating to the plasma membrane. CLIC1 is overexpressed in multiple cancers and is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLIC1 Knockout HEK293 Cell Line | EDJ-KQ2826 | Human | 1192 | Details Get a Quote |
| CLIC1 Knockout A-549 Cell Line | EDJ-KQ22431 | Human | 1192 | Details Get a Quote |
| CLIC1 Knockout HCT 116 Cell Line | EDJ-KQ23802 | Human | 1192 | Details Get a Quote |
| CLIC1 Knockout HeLa Cell Line | EDJ-KQ23803 | Human | 1192 | Details Get a Quote |
