CLEC4M
C-type lectin domain family 4 member M; DC-SIGNR; L-SIGN
Gene Information Card
| Symbol | CLEC4M |
|---|---|
| Full Name | C-type lectin domain family 4 member M |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 10332 ncbi.nlm.nih.gov/gene/10332 |
| Ensembl ID | ENSG00000104938 |
| UniProt ID | Q9H2X3 |
| OMIM ID | 605872 |
| HGNC ID | 13214 |
| Aliases | DC-SIGNR, L-SIGN, CD299, LSIGN, DC-SIGN2 |
Description
CLEC4M encodes a type II transmembrane C-type lectin receptor, also known as DC-SIGNR or L-SIGN, which functions as a pathogen recognition receptor. It binds high-mannose glycoproteins on viruses (e.g., HIV-1, Ebola, SARS-CoV) and mediates cell adhesion and immune modulation. The gene is located on chromosome 19p13.2 and is closely related to CLEC4L (DC-SIGN).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 infection | CLEC4M binds HIV-1 gp120, facilitating trans-infection of T cells | PMID: 11017103 |
| SARS-CoV infection | Receptor for SARS-CoV spike protein, mediating viral entry | PMID: 15194774 |
| Ebola virus infection | Binds Ebola glycoprotein, enhancing viral uptake | PMID: 14581545 |
| Hepatitis C virus infection | Interaction with HCV E2 glycoprotein | PMID: 14694196 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Spleen | 6.7 | Low |
| Lung | 4.2 | Low |
| Placenta | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| THP-1 | 9.8 | Monocytic leukemia cell line |
| A549 | 5.1 | Lung adenocarcinoma cell line |
| Jurkat | 1.2 | T-cell leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2287886 | SNP (promoter) | 0.15 (global) | Alters transcription factor binding, associated with HIV susceptibility |
| rs4804803 | SNP (promoter) | 0.20 (global) | Associated with altered DC-SIGNR expression |
| rs2277998 | SNP (coding synonymous) | 0.05 (global) | No known functional effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; no common loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Pathogen recognition and endocytosis (Reactome: R-HSA-168249)
• HIV infection (Reactome: R-HSA-162906)
• DC-SIGN signaling (KEGG: hsa05166)
Protein Summary
CLEC4M encodes DC-SIGNR (L-SIGN), a 399-amino acid type II transmembrane protein with a C-type lectin domain. It forms tetramers and binds mannose-rich glycans on pathogens and self-glycoproteins. Expressed primarily on liver sinusoidal endothelial cells and lymph node sinuses, it mediates pathogen capture, trans-infection of HIV-1, and immune homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC4M Knockout HEK293 Cell Line | EDJ-KQ7009 | Human | 10332 | Details Get a Quote |
| CLEC4M Knockout HeLa Cell Line | EDJ-KQ55383 | Human | 10332 | Details Get a Quote |
| CLEC4M Knockout A-549 Cell Line | EDJ-KQ63864 | Human | 10332 | Details Get a Quote |
| CLEC4M Knockout HCT 116 Cell Line | EDJ-KQ72321 | Human | 10332 | Details Get a Quote |
