CLEC4F
C-type lectin domain family 4 member F
Gene Information Card
| Symbol | CLEC4F |
|---|---|
| Full Name | C-type lectin domain family 4 member F |
| Gene Type | protein-coding |
| Chromosomal Location | 2p13.3 |
| NCBI Gene ID | 165189 ncbi.nlm.nih.gov/gene/165189 |
| Ensembl ID | ENSG00000162994 |
| UniProt ID | Q8N1N0 |
| OMIM ID | 614677 |
| HGNC ID | 13279 |
| Aliases | CLECSF13, KCLR |
Description
CLEC4F (C-type lectin domain family 4 member F) encodes a transmembrane glycoprotein belonging to the C-type lectin family. It is predominantly expressed in liver Kupffer cells and functions as a receptor for carbohydrate ligands, playing a role in pathogen recognition, endocytosis, and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Liver fibrosis | Potential role in Kupffer cell activation and hepatic stellate cell cross-talk | Expression studies in murine models |
| Hepatocellular carcinoma | Altered CLEC4F expression may correlate with tumor microenvironment changes | Gene expression profiling (NCBI GEO) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Spleen | 0.8 | Low |
| Lung | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Kupffer cells (primary) | 15.2 | High expression |
| HepG2 | 0.1 | Not detected |
| THP-1 | 0.2 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.502C>T (p.Arg168Trp) | Missense | <0.01% | Unknown functional impact |
| c.784G>A (p.Gly262Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding (GO:0030246) | • plasma membrane (GO:0005886) |
| • endocytosis (GO:0006897) | • innate immune response (GO:0045087) |
Pathways
• KEGG: hsa04625 (C-type lectin receptor signaling pathway)
Protein Summary
CLEC4F is a type II transmembrane protein with a single C-type lectin domain. It recognizes carbohydrate structures such as mannose and fucose, mediating endocytosis and pathogen clearance. The protein is highly expressed on Kupffer cells and contributes to liver immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC4F Knockout HEK293 Cell Line | EDJ-KQ12938 | Human | 165530 | Details Get a Quote |
| CLEC4F Knockout HeLa Cell Line | EDJ-KQ58888 | Human | 165530 | Details Get a Quote |
| CLEC4F Knockout A-549 Cell Line | EDJ-KQ67377 | Human | 165530 | Details Get a Quote |
| CLEC4F Knockout HCT 116 Cell Line | EDJ-KQ75770 | Human | 165530 | Details Get a Quote |
