CLEC2B (C-Type Lectin Domain Family 2 Member B)
A C-type lectin receptor involved in immune regulation and platelet activation
Gene Information Card
| Symbol | CLEC2B |
|---|---|
| Full Name | C-type lectin domain family 2 member B |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 9976 ncbi.nlm.nih.gov/gene/9976 |
| Ensembl ID | ENSG00000110848 |
| UniProt ID | Q9P126 |
| OMIM ID | 603809 |
| HGNC ID | 2055 |
| Aliases | AICL, CLECSF2, HP10085 |
Description
CLEC2B encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane glycoprotein that functions as a receptor for the platelet receptor CLEC2 (CLEC1B) and is involved in platelet activation, immune cell adhesion, and natural killer (NK) cell activation. It is expressed on various immune cells and platelets.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Platelet-type bleeding disorder | Loss of CLEC2B binding to CLEC1B impairs platelet aggregation | ClinVar |
| Infectious diseases (e.g., HIV) | CLEC2B mediates HIV-1 capture and transfer to T cells | NCBI Gene |
| Cancer (e.g., leukemia) | Altered CLEC2B expression may affect immune surveillance | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Low |
| Whole blood | 6.1 | Low |
| Bone marrow | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.2 | High expression |
| HEK 293 | 2.1 | Low expression |
| Jurkat (T-cell) | 9.8 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256G>A (p.Gly86Ser) | Missense | <0.01% | Unknown functional effect |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Potential loss of binding |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the C-type lectin domain may disrupt ligand binding.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • cell adhesion |
| • immune response | • platelet activation |
| • receptor activity |
Pathways
• Platelet activation
• signaling and aggregation
• Natural killer cell mediated cytotoxicity
• HIV life cycle
Protein Summary
CLEC2B is a 149-amino acid type II transmembrane protein with a single C-type lectin domain. It forms homodimers and binds to CLEC1B on platelets, triggering platelet activation. It also interacts with HIV-1 envelope glycoprotein, facilitating viral capture. The protein is expressed on myeloid cells, NK cells, and platelets.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC2B Knockout HEK293 Cell Line | EDJ-KQ6849 | Human | 9976 | Details Get a Quote |
| CLEC2B Knockout HeLa Cell Line | EDJ-KQ55291 | Human | 9976 | Details Get a Quote |
| CLEC2B Knockout A-549 Cell Line | EDJ-KQ63773 | Human | 9976 | Details Get a Quote |
| CLEC2B Knockout HCT 116 Cell Line | EDJ-KQ72232 | Human | 9976 | Details Get a Quote |
