CLEC14A
C-Type Lectin Domain Containing 14A
Gene Information Card
| Symbol | CLEC14A |
|---|---|
| Full Name | C-type lectin domain containing 14A |
| Gene Type | protein-coding |
| Chromosomal Location | 14q21.1 |
| NCBI Gene ID | 161198 ncbi.nlm.nih.gov/gene/161198 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q86T13 |
| OMIM ID | 616845 |
| HGNC ID | 28731 |
| Aliases | CEG1, UNQ236/PRO269 |
Description
CLEC14A encodes a C-type lectin domain-containing protein that functions as a cell surface receptor. It is predominantly expressed in endothelial cells and is upregulated in tumor vasculature, suggesting a role in angiogenesis and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression in tumor endothelium promotes angiogenesis | PMID: 22174317 |
| Colorectal cancer | CLEC14A expression correlates with tumor stage and metastasis | PMID: 25605248 |
| Lung cancer | Upregulated in non-small cell lung cancer vasculature | PMID: 23454750 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Medium |
| Placenta | 4.8 | Medium |
| Heart | 3.1 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (umbilical vein endothelial) | 12.3 | High expression |
| A549 (lung carcinoma) | 2.1 | Low expression |
| HeLa (cervical carcinoma) | 1.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005515 (protein binding) | • GO:0005886 (plasma membrane) |
| • GO:0038023 (signaling receptor activity) | • GO:0001525 (angiogenesis) |
Pathways
• Angiogenesis (Reactome: R-HSA-194315)
• Cell surface interactions at the vascular wall (Reactome: R-HSA-202733)
Protein Summary
CLEC14A is a transmembrane protein with a C-type lectin domain, involved in cell adhesion and angiogenesis. It is highly expressed in endothelial cells and tumor vasculature, making it a potential target for anti-angiogenic therapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC14A Knockout HEK293 Cell Line | EDJ-KQ12942 | Human | 161198 | Details Get a Quote |
| CLEC14A Knockout HeLa Cell Line | EDJ-KQ58823 | Human | 161198 | Details Get a Quote |
| CLEC14A Knockout A-549 Cell Line | EDJ-KQ67307 | Human | 161198 | Details Get a Quote |
| CLEC14A Knockout HCT 116 Cell Line | EDJ-KQ75706 | Human | 161198 | Details Get a Quote |
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