CLEC11A: C-Type Lectin Domain Family 11 Member A
A secreted sulfated glycoprotein involved in osteogenesis and hematopoiesis
Gene Information Card
| Symbol | CLEC11A |
|---|---|
| Full Name | C-type lectin domain family 11 member A |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 6320 ncbi.nlm.nih.gov/gene/6320 |
| Ensembl ID | ENSG00000105472 |
| UniProt ID | Q9Y240 |
| OMIM ID | 604827 |
| HGNC ID | 10523 |
| Aliases | SCGF, CLECSF3, LSLCL, P47 |
Description
CLEC11A encodes a secreted sulfated glycoprotein belonging to the C-type lectin domain family. It functions as a growth factor for hematopoietic stem cells and plays a critical role in osteogenesis by promoting osteoblast differentiation and bone formation. The protein is also involved in cell adhesion and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoporosis | Reduced CLEC11A expression impairs osteoblast differentiation and bone mineral density, contributing to bone loss. | ClinVar, OMIM |
| Hematopoietic disorders | CLEC11A acts as a stem cell growth factor; altered expression may affect hematopoietic stem cell proliferation and differentiation. | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Kidney | 4.7 | Low |
| Liver | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.0 | High expression |
| HepG2 (liver cancer) | 7.8 | Moderate expression |
| A549 (lung cancer) | 5.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional effect; rare population variant |
| c.454G>A (p.Gly152Ser) | Missense | <0.01% | Unknown functional effect; rare population variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hematopoietic stem cell differentiation
• Osteoblast differentiation and bone mineralization
Protein Summary
CLEC11A is a secreted glycoprotein of 323 amino acids (UniProt Q9Y240). It contains a C-type lectin domain and is synthesized as a precursor that is proteolytically processed. The mature protein acts as a growth factor for hematopoietic stem cells and promotes osteoblast differentiation. It is expressed in bone marrow, spleen, and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC11A Knockout HEK293 Cell Line | EDJ-KQ5717 | Human | 6320 | Details Get a Quote |
| CLEC11A Knockout A-549 Cell Line | EDJ-KQ29105 | Human | 6320 | Details Get a Quote |
| CLEC11A Knockout HCT 116 Cell Line | EDJ-KQ29106 | Human | 6320 | Details Get a Quote |
| CLEC11A Knockout HeLa Cell Line | EDJ-KQ54396 | Human | 6320 | Details Get a Quote |
