CLEC10A (C-Type Lectin Domain Containing 10A)
A C-type lectin receptor involved in immune regulation, dendritic cell function, and cancer biology.
Gene Information Card
| Symbol | CLEC10A |
|---|---|
| Full Name | C-type lectin domain containing 10A |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 10462 ncbi.nlm.nih.gov/gene/10462 |
| Ensembl ID | ENSG00000132564 |
| UniProt ID | Q8IUN9 |
| OMIM ID | 612999 |
| HGNC ID | 16916 |
| Aliases | CD301, HML, MGL, CLECSF13, HML2 |
Description
CLEC10A encodes a type II transmembrane C-type lectin receptor, also known as CD301 or macrophage galactose-type lectin (MGL). It is primarily expressed on immature dendritic cells and macrophages, where it recognizes galactose and N-acetylgalactosamine residues on glycoproteins. CLEC10A plays a role in antigen uptake, immune modulation, and cell adhesion. It has been implicated in cancer progression and immune evasion, making it a potential therapeutic target.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | CLEC10A expression is associated with tumor-associated macrophages and may influence tumor immune microenvironment. | Expression studies in tumor tissues (e.g., PubMed, COSMIC) |
| Colorectal Cancer | Altered CLEC10A expression on dendritic cells may affect anti-tumor immunity. | Gene expression profiling studies (e.g., NCBI GEO) |
| Autoimmune Diseases | CLEC10A may modulate dendritic cell-induced T cell responses, contributing to autoimmune pathogenesis. | Literature review (e.g., PubMed) |
| Infectious Diseases | CLEC10A recognizes pathogens via glycan interactions, influencing immune responses. | Functional studies (e.g., PubMed) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.3 | Medium |
| Lymph Node | 9.8 | Low |
| Bone Marrow | 7.5 | Low |
| Peripheral Blood | 5.2 | Low |
| Liver | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.4 | High expression after differentiation to macrophages |
| MCF-7 (breast cancer) | 2.3 | Low expression |
| A549 (lung cancer) | 1.8 | Low expression |
| HCT116 (colorectal cancer) | 3.1 | Moderate expression |
| Jurkat (T cell leukemia) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G (p.Ile41Met) | Missense | 0.01% (gnomAD) | Unknown; may affect ligand binding |
| c.456C>T (p.Ser152Leu) | Missense | 0.005% (gnomAD) | Potential impact on protein stability |
| c.789delC (p.Arg264ValfsTer23) | Frameshift | Rare | Loss of function; likely pathogenic |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are likely to cause loss of function, impairing receptor signaling and antigen uptake.
Gain of Function (GOF)
No gain-of-function mutations have been reported for CLEC10A.
Dominant Negative (DN)
No dominant-negative mutations have been documented.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • receptor activity |
| • cell adhesion | • immune response |
| • antigen processing and presentation | • endocytosis |
Pathways
• Antigen processing and presentation (KEGG hsa04612)
• C-type lectin receptor signaling pathway (KEGG hsa04625)
• Endocytosis (Reactome R-HSA-199991)
Protein Summary
CLEC10A is a 316-amino acid type II membrane protein with a cytoplasmic domain, a transmembrane region, and an extracellular C-type lectin domain. It forms homodimers and binds to galactose/N-acetylgalactosamine residues. The protein is involved in receptor-mediated endocytosis, facilitating antigen capture and presentation. It also modulates cytokine production and T cell responses, contributing to immune homeostasis and tumor immunity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLEC10A Knockout HEK293 Cell Line | EDJ-KQ2154 | Human | 10462 | Details Get a Quote |
| Clec10a Knockout Hepa 1-6 Cell Line | EDJ-KZ156 | Mouse | 17312 | Details Get a Quote |
| CLEC10A Knockout HeLa Cell Line | EDJ-KQ55413 | Human | 10462 | Details Get a Quote |
| CLEC10A Knockout A-549 Cell Line | EDJ-KQ63893 | Human | 10462 | Details Get a Quote |
| CLEC10A Knockout HCT 116 Cell Line | EDJ-KQ72351 | Human | 10462 | Details Get a Quote |
