CLDN25
Claudin 25: A Tight Junction Protein with Limited Characterized Function
Gene Information Card
| Symbol | CLDN25 |
|---|---|
| Full Name | Claudin 25 |
| Gene Type | Protein coding |
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 100130159 ncbi.nlm.nih.gov/gene/100130159 |
| Ensembl ID | ENSG00000205571 |
| UniProt ID | Q96FQ6 |
| OMIM ID | 617837 |
| HGNC ID | 40009 |
| Aliases | CLDNL1, claudin-like 1 |
Description
CLDN25 (claudin 25) is a protein-coding gene that belongs to the claudin family of tight junction proteins. Claudins are integral membrane proteins that form the paracellular barrier in epithelial and endothelial cell sheets. CLDN25 is predicted to be involved in cell-cell adhesion and maintenance of tissue integrity. Its specific physiological roles and tissue distribution are not fully characterized, and it is considered a less-studied member of the claudin family.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.4 | Low |
| Kidney | 0.2 | Low |
| Brain | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.3 | Low expression |
| K562 | 0.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • cell-cell junction (GO:0005911) | • lateral plasma membrane (GO:0016328) |
| • cell junction (GO:0030054) | • structural molecule activity (GO:0005198) |
Pathways
• Tight junction (KEGG: hsa04530)
Protein Summary
Claudin 25 is a predicted four-transmembrane domain protein with structural similarity to other claudins. It is thought to localize to tight junctions and contribute to paracellular transport regulation. The protein has not been extensively studied at the functional level, and its specific binding partners and tissue-specific roles remain largely unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLDN25 Knockout HEK293 Cell Line | EDJ-KQ12931 | Human | 644672 | Details Get a Quote |
| CLDN25 Knockout HeLa Cell Line | EDJ-KQ60573 | Human | 644672 | Details Get a Quote |
| CLDN25 Knockout A-549 Cell Line | EDJ-KQ69044 | Human | 644672 | Details Get a Quote |
| CLDN25 Knockout HCT 116 Cell Line | EDJ-KQ77398 | Human | 644672 | Details Get a Quote |
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