CLDN23
Claudin 23, a tight junction protein involved in epithelial barrier function and gastric cancer
Gene Information Card
| Symbol | CLDN23 |
|---|---|
| Full Name | claudin 23 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p23.1 |
| NCBI Gene ID | 137075 ncbi.nlm.nih.gov/gene/137075 |
| Ensembl ID | ENSG00000164754 |
| UniProt ID | Q96B33 |
| OMIM ID | 609203 |
| HGNC ID | 17593 |
| Aliases | CLDN23, claudin-23, FLJ20060 |
Description
CLDN23 (claudin 23) is a protein-coding gene that belongs to the claudin family of tight junction proteins. Claudins are integral membrane proteins that form the paracellular barrier in epithelial and endothelial cell sheets, controlling the flow of molecules between cells. CLDN23 is specifically expressed in the stomach and is involved in gastric epithelial barrier integrity. Altered expression has been linked to gastric cancer and other gastrointestinal disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Downregulation of CLDN23 disrupts tight junctions, increasing paracellular permeability and promoting tumor invasion. | PMID: 16990144; NCBI Gene |
| Helicobacter pylori infection | Reduced CLDN23 expression correlates with H. pylori-induced gastric epithelial barrier dysfunction. | PMID: 20026030 |
| Inflammatory bowel disease | Altered claudin expression, including CLDN23, contributes to intestinal barrier defects. | PMID: 23300010 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 28.5 | High |
| Esophagus | 6.2 | Medium |
| Duodenum | 4.8 | Medium |
| Colon | 2.1 | Low |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MKN45 (gastric cancer) | 15.2 | Moderate expression |
| AGS (gastric adenocarcinoma) | 12.8 | Moderate expression |
| Caco-2 (colorectal) | 3.5 | Low expression |
| HEK293 (embryonic kidney) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect; reported in COSMIC |
| c.124G>A (p.Gly42Ser) | Missense | <0.01% | Reported in COSMIC; no known disease association |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Not established.
Dominant Negative (DN)
Not established.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Tight junction (KEGG: hsa04530)
• Cell adhesion molecules (CAMs) (KEGG: hsa04514)
Protein Summary
Claudin-23 is a 224-amino acid transmembrane protein with four transmembrane domains, two extracellular loops, and intracellular N- and C-termini. It localizes to tight junctions in epithelial cells, particularly in the gastric mucosa. The protein interacts with other claudins to form paracellular pores and seals. Its expression is frequently downregulated in gastric cancer, suggesting a tumor-suppressive role in maintaining epithelial integrity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLDN23 Knockout HEK293 Cell Line | EDJ-KQ9387 | Human | 137075 | Details Get a Quote |
| CLDN23 Knockout A-549 Cell Line | EDJ-KQ36035 | Human | 137075 | Details Get a Quote |
| CLDN23 Knockout HCT 116 Cell Line | EDJ-KQ36036 | Human | 137075 | Details Get a Quote |
| CLDN23 Knockout HeLa Cell Line | EDJ-KQ36037 | Human | 137075 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
