CLC (Charcot-Leyden Crystal Galectin)

A galectin protein with lysophospholipase activity, primarily expressed in eosinophils and basophils, associated with allergic inflammation and eosinophilic disorders.

Gene Information Card

Symbol CLC
Full Name Charcot-Leyden Crystal Galectin
Gene Type protein-coding
Chromosomal Location 19q13.2
NCBI Gene ID 1178 ncbi.nlm.nih.gov/gene/1178
Ensembl ID ENSG00000105205
UniProt ID Q05315
OMIM ID 153310
HGNC ID 2014
Aliases LGALS10, galectin-10, Charcot-Leyden crystal protein, lysophospholipase

Description

The CLC gene encodes the Charcot-Leyden crystal protein, also known as galectin-10. This protein is a member of the galectin family and possesses lysophospholipase activity. It is predominantly expressed in eosinophils and basophils and forms characteristic hexagonal bipyramidal crystals (Charcot-Leyden crystals) in tissues and secretions associated with allergic inflammation and eosinophilic disorders. The protein is involved in immune modulation, cell migration, and inflammatory responses.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Eosinophilic esophagitis CLC protein forms Charcot-Leyden crystals in esophageal tissue, contributing to inflammation and tissue damage ClinVar, literature
Eosinophilic asthma CLC expression elevated in sputum and bronchial biopsies; crystals associated with airway inflammation NCBI Gene, literature
Hypereosinophilic syndrome CLC overexpression and crystal deposition in multiple organs OMIM, literature
Allergic rhinitis CLC detected in nasal secretions as crystals, linked to eosinophilic inflammation UniProt, literature

Expression Profile

Tissue Expression
Tissue nTPM level
Bone marrow 12.5 Medium
Spleen 8.2 Low
Lung 6.7 Low
Small intestine 5.1 Low
Blood (leukocytes) 4.3 Low
Cell Line Expression
Cell Line nTPM Notes
Eosinophils (primary) High Major source of CLC expression
Basophils (primary) Moderate Second major cell type
HL-60 (promyeloblast) Low Differentiation-dependent expression
K-562 (erythroleukemia) Not detected No significant expression
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.1A>G (p.Met1?) Missense Rare Potential loss of start codon; functional impact unknown
c.124G>A (p.Gly42Ser) Missense Rare Unknown effect on lysophospholipase activity
c.337C>T (p.Arg113Trp) Missense Rare Reported in ClinVar; uncertain significance
Mutation functional classification

Loss of Function (LOF)

No well-characterized loss-of-function mutations reported in CLC.

Gain of Function (GOF)

No gain-of-function mutations described.

Dominant Negative (DN)

No dominant-negative mutations known.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/1178
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CLC

Gene Ontology (GO)

• lysophospholipase activity (GO:0004622) • carbohydrate binding (GO:0030246)
• extracellular region (GO:0005576) • extracellular space (GO:0005615)
• immune response (GO:0006955) • regulation of inflammatory response (GO:0050727)

Pathways

• Galectin pathway (Reactome: R-HSA-5621481)
• Eosinophil degranulation (Reactome: R-HSA-6798695)

Protein Summary

The Charcot-Leyden crystal protein (galectin-10) is a 17.5 kDa protein with lysophospholipase activity. It forms hexagonal bipyramidal crystals in eosinophil-rich environments. The protein is involved in immune modulation, cell adhesion, and inflammatory signaling. Its crystal formation is a hallmark of eosinophilic inflammation in diseases such as asthma, eosinophilic esophagitis, and hypereosinophilic syndrome.

Related Services

Knockout Cell Line
Point Mutation Cell Line
Knock-In Cell Line
Overexpression Cell Line
Knockdown Cell Line
Reporter Cell Line
Knock-in Tag
iPSC Gene Editing

Related Products

Product name Cat.No. Species Gene ID
CLCN1 Knockout HEK293 Cell Line EDJ-KQ2129 Human 1180 Details Get a Quote
CLCN6 Knockout HEK293 Cell Line EDJ-KQ2569 Human 1185 Details Get a Quote
CLCN2 Knockout HEK293 Cell Line EDC09609 Human 1181 Details Get a Quote
CLCN5 Knockout HEK293 Cell Line EDJ-KQ2995 Human 1184 Details Get a Quote
CLCN7 Knockout HEK293 Cell Line EDJ-KQ3589 Human 1186 Details Get a Quote
CLC Knockout HEK293 Cell Line EDJ-KQ4283 Human 1178 Details Get a Quote
CLCA1 Knockout HEK293 Cell Line EDJ-KQ4285 Human 1179 Details Get a Quote
CLCNKB Knockout HEK293 Cell Line EDJ-KQ4287 Human 1188 Details Get a Quote
CLCN4 Knockout HEK293 Cell Line EDJ-KQ4288 Human 1183 Details Get a Quote
CLCNKA Knockout HEK293 Cell Line EDJ-KQ4289 Human 1187 Details Get a Quote
CLCN3 Knockout HEK293 Cell Line EDJ-KQ4291 Human 1182 Details Get a Quote
CLCA2 Knockout HEK293 Cell Line EDJ-KQ6668 Human 9635 Details Get a Quote
CLCC1 Knockout HEK293 Cell Line EDJ-KQ7173 Human 23155 Details Get a Quote
CLCA4 Knockout HEK293 Cell Line EDJ-KQ7677 Human 22802 Details Get a Quote
CLCF1 Knockout HEK293 Cell Line EDJ-KQ8046 Human 23529 Details Get a Quote

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/1178
OMIM https://www.omim.org/entry/153310
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2014
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105205
UniProt https://www.uniprot.org/uniprot/Q05315
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=CLC%5Bgene%5D
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CLC
Contact Us
*
*
*
How did you hear about us：
✖ service online