CKS1B Gene - CDC28 Protein Kinase Regulatory Subunit 1B | NCBI, UniProt, OMIM

CKS1B (CDC28 protein kinase regulatory subunit 1B) is a protein-coding gene that encodes a member of the cyclin-dependent kinase (CDK) regulatory subunit family. The protein binds to the catalytic subunit of CDKs and is essential for their biological function, particularly in cell cycle progression. CKS1B is involved in the regulation of the G1/S and G2/M transitions of the cell cycle. It also plays a role in ubiquitin-mediated proteolysis and is implicated in various cancers, including multiple myeloma and breast cancer.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Cell Cycle (KEGG: hsa04110)

• Ubiquitin mediated proteolysis (KEGG: hsa04120)

• p53 signaling pathway (KEGG: hsa04115)

• FoxO signaling pathway (KEGG: hsa04068)

CKS1B is a small protein (79 amino acids) that functions as a regulatory subunit of cyclin-dependent kinases (CDKs). It binds to CDK1 and CDK2, modulating their activity and substrate specificity. CKS1B is essential for proper cell cycle progression, particularly at the G1/S and G2/M checkpoints. It also participates in the ubiquitin-proteasome system by interacting with the SCF ubiquitin ligase complex, targeting cell cycle regulators such as p27Kip1 for degradation. Overexpression of CKS1B is frequently observed in various cancers and is associated with poor prognosis.