CKLF (Chemokine-Like Factor) Gene: Structure, Function, and Disease Associations
A comprehensive biomedical resource on the CKLF gene, including genomic data, expression profiles, mutations, and clinical relevance.
Gene Information Card
| Symbol | CKLF |
|---|---|
| Full Name | chemokine-like factor |
| Gene Type | protein-coding |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 51192 ncbi.nlm.nih.gov/gene/51192 |
| Ensembl ID | ENSG00000103175 |
| UniProt ID | Q9UBR5 |
| OMIM ID | 605173 |
| HGNC ID | 17153 |
| Aliases | CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1 |
Description
CKLF (chemokine-like factor) is a protein-coding gene located on chromosome 16q21. It encodes a cytokine with chemokine-like properties, involved in immune regulation, inflammation, and cell proliferation. Multiple splice variants exist, with CKLF1 being the most studied. The gene is expressed in various tissues and has been implicated in autoimmune diseases, cancer, and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid arthritis | CKLF promotes chemotaxis of immune cells and synovial inflammation | PMID: 15609323 |
| Asthma | CKLF overexpression enhances airway inflammation and eosinophil recruitment | PMID: 16982621 |
| Gastric cancer | CKLF upregulation correlates with tumor progression and metastasis | PMID: 21573172 |
| Systemic lupus erythematosus | CKLF may contribute to aberrant immune activation | PMID: 19732725 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 18.3 | Medium |
| Bone marrow | 22.1 | High |
| Thymus | 15.7 | Medium |
| Liver | 8.4 | Low |
| Kidney | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.2 | Embryonic kidney cells |
| HeLa | 11.8 | Cervical carcinoma cells |
| K562 | 20.5 | Chronic myelogenous leukemia cells |
| Jurkat | 16.9 | T-cell leukemia cells |
| HepG2 | 9.1 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | p.Met1Val; potential loss of start codon |
| c.124C>T | Nonsense | 0.005% | p.Arg42*; premature truncation |
| c.256G>A | Missense | 0.02% | p.Gly86Ser; altered protein function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg42*) lead to truncated protein and loss of chemokine activity.
Gain of Function (GOF)
Not well documented; some missense variants may enhance chemotactic activity.
Dominant Negative (DN)
Not reported for CKLF.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • extracellular space (GO:0005615) |
| • protein binding (GO:0005515) |
Pathways
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Chemokine signaling pathway (KEGG: hsa04062)
Protein Summary
The CKLF protein (UniProt Q9UBR5) is a small secreted chemokine-like factor of 99 amino acids (CKLF1 isoform). It contains a conserved CC chemokine motif and functions as a chemoattractant for leukocytes, including monocytes, lymphocytes, and neutrophils. CKLF also promotes cell proliferation and angiogenesis. Alternative splicing generates multiple isoforms with varying activities.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CKLF Knockout HEK293 Cell Line | EDJ-KQ51291 | Human | 51192 | Details Get a Quote |
| CKLF-CMTM1 Knockout HEK293 Cell Line | EDJ-KQ52498 | Human | 100529251 | Details Get a Quote |
| CKLF Knockout HeLa Cell Line | EDJ-KQ56247 | Human | 51192 | Details Get a Quote |
| CKLF-CMTM1 Knockout HeLa Cell Line | EDJ-KQ60961 | Human | 100529251 | Details Get a Quote |
| CKLF Knockout A-549 Cell Line | EDJ-KQ64736 | Human | 51192 | Details Get a Quote |
| CKLF-CMTM1 Knockout A-549 Cell Line | EDJ-KQ69436 | Human | 100529251 | Details Get a Quote |
| CKLF Knockout HCT 116 Cell Line | EDJ-KQ73181 | Human | 51192 | Details Get a Quote |
| CKLF-CMTM1 Knockout HCT 116 Cell Line | EDJ-KQ77787 | Human | 100529251 | Details Get a Quote |
