CHTOP Gene (Chromatin Target of PRMT1)
A key regulator of chromatin structure, mRNA processing, and tumorigenesis
Gene Information Card
| Symbol | CHTOP |
|---|---|
| Full Name | Chromatin Target Of PRMT1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 26097 ncbi.nlm.nih.gov/gene/26097 |
| Ensembl ID | ENSG00000116285 |
| UniProt ID | Q9Y3Y2 |
| OMIM ID | 610296 |
| HGNC ID | 24518 |
| Aliases | FOP, C1orf77, SRAG, FLJ21908 |
Description
CHTOP (Chromatin Target Of PRMT1) encodes a small nuclear protein that shuttles between the nucleus and cytoplasm. It is involved in chromatin remodeling, mRNA processing, and transcriptional regulation. CHTOP interacts with PRMT1 to modulate histone arginine methylation and is also a component of the TREX complex, facilitating mRNA export. Overexpression and mutations of CHTOP have been implicated in various cancers, including glioblastoma and breast cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | CHTOP overexpression promotes tumor cell proliferation and invasion via altered mRNA processing and PRMT1-mediated chromatin changes. | PMID: 23431136, COSMIC |
| Breast Cancer | CHTOP amplification and high expression correlate with poor prognosis; regulates estrogen receptor signaling and cell cycle genes. | PMID: 25609607, COSMIC |
| Colorectal Cancer | CHTOP upregulation associated with metastasis and chemoresistance through modulation of Wnt/β-catenin pathway. | PMID: 29367642, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Colon | 7.1 | Medium |
| Lung | 6.9 | Medium |
| Liver | 4.2 | Low |
| Testis | 15.8 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
| U87MG | 18.7 | Glioblastoma cell line |
| HCT116 | 9.8 | Colorectal cancer cell line |
| HEK293 | 6.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374A>G (p.Gln125Arg) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Potential loss of interaction with PRMT1 |
| Amplification | Copy number gain | 1-2% in glioblastoma | Increased CHTOP expression; oncogenic |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Amplification and overexpression are associated with oncogenic gain-of-function in glioblastoma and breast cancer.
Dominant Negative (DN)
Not described for CHTOP.
View complete mutation data：
Gene Ontology (GO)
| • nucleus (GO:0005634) | • nucleoplasm (GO:0005654) |
| • cytosol (GO:0005829) | • RNA binding (GO:0003723) |
| • mRNA processing (GO:0006397) | • RNA export from nucleus (GO:0006405) |
| • intracellular ribonucleoprotein complex (GO:0030529) | • identical protein binding (GO:0042802) |
Pathways
• TREX complex pathway (mRNA export)
• PRMT1-mediated chromatin remodeling
• Estrogen receptor signaling (breast cancer)
Protein Summary
CHTOP is a 25 kDa nuclear protein that contains a glycine-arginine-rich (GAR) domain and a C-terminal domain. It binds RNA and interacts with PRMT1, promoting arginine methylation of histones and other proteins. As part of the TREX complex, CHTOP facilitates the export of spliced mRNA from the nucleus to the cytoplasm. Its overexpression in cancers suggests a role in tumor progression by enhancing mRNA processing and export of oncogenic transcripts.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHTOP Knockout HEK293 Cell Line | EDJ-KQ8402 | Human | 26097 | Details Get a Quote |
| CHTOP Knockout HeLa Cell Line | EDJ-KQ33141 | Human | 26097 | Details Get a Quote |
| CHTOP Knockout A-549 Cell Line | EDJ-KQ34474 | Human | 26097 | Details Get a Quote |
| CHTOP Knockout HCT 116 Cell Line | EDJ-KQ34475 | Human | 26097 | Details Get a Quote |
