CHRDL2 Gene (Chordin-Like 2)
Gene, Function, Expression, and Disease Associations
Gene Information Card
| Symbol | CHRDL2 |
|---|---|
| Full Name | Chordin-Like 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 11q14.1 |
| NCBI Gene ID | 25884 ncbi.nlm.nih.gov/gene/25884 |
| Ensembl ID | ENSG00000149269 |
| UniProt ID | Q6WN34 |
| OMIM ID | 612400 |
| HGNC ID | 29865 |
| Aliases | BMPER, CRDL2, MGC45474 |
Description
CHRDL2 (Chordin-Like 2) encodes a secreted protein that functions as a bone morphogenetic protein (BMP) antagonist. It binds BMPs and inhibits their signaling, playing a role in embryonic development, particularly in bone and cartilage formation. The gene is also implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoarthritis | Altered BMP signaling due to CHRDL2 dysregulation may affect cartilage homeostasis. | PMID: 21871566 |
| Colorectal Cancer | CHRDL2 overexpression may promote tumor growth via BMP pathway modulation. | PMID: 23542377 |
| Breast Cancer | CHRDL2 expression changes correlate with tumor progression and metastasis. | PMID: 25636836 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone | 0.5 | Low |
| Cartilage | 1.2 | Medium |
| Brain | 0.3 | Low |
| Heart | 0.1 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.8 | Low expression |
| MCF7 | 1.5 | Medium expression |
| HCT116 | 2.1 | Medium-high expression |
| A549 | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.245C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.245C>T) are predicted to cause loss of function by introducing a premature stop codon.
Gain of Function (GOF)
No gain-of-function mutations have been reported in CHRDL2.
Dominant Negative (DN)
No dominant-negative mutations have been described for CHRDL2.
View complete mutation data：
Gene Ontology (GO)
| • BMP binding | • BMP signaling pathway |
| • extracellular region | • negative regulation of BMP signaling pathway |
Pathways
• BMP signaling pathway (Reactome: R-HSA-201451)
Protein Summary
CHRDL2 is a secreted protein of 428 amino acids (UniProt Q6WN34) that contains a chordin-like domain. It acts as an antagonist of BMP signaling by binding BMP ligands and preventing their interaction with receptors. The protein is involved in developmental processes and has been linked to cancer and osteoarthritis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHRDL2 Knockout HEK293 Cell Line | EDJ-KQ8281 | Human | 25884 | Details Get a Quote |
| CHRDL2 Knockout A-549 Cell Line | EDJ-KQ34233 | Human | 25884 | Details Get a Quote |
| CHRDL2 Knockout HeLa Cell Line | EDJ-KQ34234 | Human | 25884 | Details Get a Quote |
| CHRDL2 Knockout HCT 116 Cell Line | EDJ-KQ72784 | Human | 25884 | Details Get a Quote |
