CHP2 (Calcineurin B Homologous Protein 2)
A calcium-binding protein involved in pH regulation and cell proliferation
Gene Information Card
| Symbol | CHP2 |
|---|---|
| Full Name | Calcineurin B Homologous Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p12.1 |
| NCBI Gene ID | 63928 ncbi.nlm.nih.gov/gene/63928 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | Q9Y2V0 |
| OMIM ID | 609205 |
| HGNC ID | 24327 |
| Aliases | HCA520, p22 |
Description
CHP2 encodes a calcium-binding protein that is a member of the calcineurin B-like family. It functions as an essential cofactor for the sodium-hydrogen exchanger NHE1 (SLC9A1), regulating intracellular pH and cell volume. CHP2 is also implicated in cell proliferation and tumorigenesis, with overexpression observed in several cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Overexpression of CHP2 enhances NHE1 activity, promoting cell proliferation and resistance to apoptosis | PMID: 16936731 |
| Hepatocellular carcinoma | CHP2 upregulation correlates with increased tumor growth and poor prognosis | PMID: 21750193 |
| Colorectal cancer | CHP2 expression is elevated and associated with NHE1-mediated pH regulation | PMID: 22952447 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Low |
| Stomach | 6.7 | Low |
| Colon | 5.9 | Low |
| Heart | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 10.8 | Moderate expression |
| MCF7 | 7.4 | Low expression |
| HepG2 | 9.1 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional impact |
| c.124C>T | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Regulation of intracellular pH (Reactome: R-HSA-425986)
• Sodium/proton exchanger (NHE) regulation (Reactome: R-HSA-425986)
Protein Summary
CHP2 is a 22 kDa calcium-binding protein that shares homology with calcineurin B. It binds to the cytoplasmic tail of NHE1, modulating its activity in response to calcium signals. CHP2 is predominantly expressed in kidney and liver, with lower levels in gastrointestinal tissues. Its overexpression in cancers suggests a role in tumor progression through pH homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHP2 Knockout HEK293 Cell Line | EDJ-KQ12913 | Human | 63928 | Details Get a Quote |
| CHP2 Knockout HeLa Cell Line | EDJ-KQ56999 | Human | 63928 | Details Get a Quote |
| CHP2 Knockout A-549 Cell Line | EDJ-KQ65503 | Human | 63928 | Details Get a Quote |
| CHP2 Knockout HCT 116 Cell Line | EDJ-KQ73940 | Human | 63928 | Details Get a Quote |
