CGB7 Gene - Chorionic Gonadotropin Subunit Beta 7 | NCBI, UniProt, OMIM

CGB7 (chorionic gonadotropin subunit beta 7) is a protein-coding gene located on chromosome 19q13.33. It encodes the beta subunit of human chorionic gonadotropin (hCG), a glycoprotein hormone essential for maintaining pregnancy. The beta subunit confers biological specificity to the hormone. CGB7 is part of a cluster of closely related beta subunit genes on chromosome 19. Expression is predominantly in the placenta, with lower levels in other tissues. The protein product is a key component of hCG, which signals through the luteinizing hormone/choriogonadotropin receptor (LHCGR) to support corpus luteum function and early pregnancy.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• hCG signaling pathway (Reactome: R-HSA-378563)

• Glycoprotein hormone biosynthesis (Reactome: R-HSA-378565)

• GPCR downstream signaling (Reactome: R-HSA-388396)

The CGB7 protein is a 165-amino acid polypeptide that forms the beta subunit of human chorionic gonadotropin (hCG). It is synthesized as a preproprotein and undergoes post-translational modification including glycosylation. The mature beta subunit non-covalently associates with the common alpha subunit (CGA) to form the functional hCG heterodimer. hCG binds to the LHCGR receptor on target cells, activating G-protein coupled signaling cascades that promote steroidogenesis and maintain pregnancy. CGB7 is one of several highly similar beta subunit genes; its specific role in hCG function is not fully distinguished from other family members.