CEMP1 (Cementum Protein 1)
Key regulator of cementoblast differentiation and periodontal tissue mineralization
Gene Information Card
| Symbol | CEMP1 |
|---|---|
| Full Name | Cementum Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 752014 ncbi.nlm.nih.gov/gene/752014 |
| Ensembl ID | ENSG00000206190 |
| UniProt ID | Q6PUV4 |
| OMIM ID | 610099 |
| HGNC ID | 33706 |
| Aliases | CP-23, CEMP-1, cementum-derived protein |
Description
CEMP1 (cementum protein 1) is a gene that encodes a secreted protein specifically expressed in cementoblasts and periodontal ligament cells. It plays a critical role in cementum formation, mineralization, and periodontal tissue homeostasis. The protein promotes hydroxyapatite nucleation and regulates osteoblast/cementoblast differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Periodontal disease | Reduced CEMP1 expression impairs cementum repair and regeneration | PMID: 20626526 |
| Hypophosphatasia | Altered mineralization pathways involving CEMP1 downregulation | PMID: 23441117 |
| Tooth root resorption | Aberrant CEMP1 expression linked to cementoclast activity | PMID: 25655882 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Periodontal ligament | 12.5 | Medium |
| Gingiva | 8.3 | Low |
| Salivary gland | 2.1 | Not detected |
| Bone marrow | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cementoblast-like cell line (OCCM-30) | 15.2 | High expression |
| Periodontal ligament fibroblasts | 9.8 | Moderate expression |
| MG-63 osteosarcoma | 3.4 | Low expression |
| HEK293 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon |
| c.214C>T (p.Arg72Cys) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CEMP1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CEMP1.
Dominant Negative (DN)
No dominant-negative mutations described for CEMP1.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • biomineral tissue development (GO:0031214) |
| • integrin binding (GO:0005178) | • cell adhesion (GO:0007155) |
| • bone mineralization (GO:0030282) |
Pathways
• Mineralization and cementogenesis pathway
• Integrin signaling pathway
Protein Summary
Cementum protein 1 (CEMP1) is a 23 kDa secreted phosphoprotein that binds hydroxyapatite and promotes mineralization. It is specifically expressed in cementoblasts and periodontal ligament cells, where it regulates cell attachment, differentiation, and extracellular matrix deposition. CEMP1 is considered a key marker for cementoblast lineage and a potential therapeutic target for periodontal regeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CEMP1 Knockout HEK293 Cell Line | EDJ-KQ12858 | Human | 752014 | Details Get a Quote |
| CEMP1 Knockout A-549 Cell Line | EDJ-KQ42020 | Human | 752014 | Details Get a Quote |
| CEMP1 Knockout HCT 116 Cell Line | EDJ-KQ42021 | Human | 752014 | Details Get a Quote |
| CEMP1 Knockout HeLa Cell Line | EDJ-KQ42022 | Human | 752014 | Details Get a Quote |
