CELA3B
Chymotrypsin Like Elastase 3B
Gene Information Card
| Symbol | CELA3B |
|---|---|
| Full Name | Chymotrypsin Like Elastase 3B |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 23436 ncbi.nlm.nih.gov/gene/23436 |
| Ensembl ID | ENSG00000196411 |
| UniProt ID | P08861 |
| OMIM ID | 609443 |
| HGNC ID | 16285 |
| Aliases | ELA3B, elastase 3B, pancreatic elastase IIIB |
Description
CELA3B encodes a member of the chymotrypsin-like elastase family of serine proteases. The encoded preproprotein is proteolytically processed to generate the active enzyme, which is secreted by the pancreas and participates in the digestion of dietary proteins. This gene is specifically expressed in the pancreas and its product is a major component of pancreatic juice.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatitis | Dysregulation of pancreatic proteases; CELA3B variants may alter enzyme activity or zymogen activation, contributing to autodigestion | ClinVar |
| Pancreatic cancer | Altered expression or mutations in CELA3B may influence tumor microenvironment and protease balance | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 1234.5 | High |
| Salivary gland | 12.3 | Low |
| Stomach | 5.6 | Not detected |
| Small intestine | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 890.1 | Pancreatic cancer cell line |
| MIA PaCa-2 | 765.4 | Pancreatic cancer cell line |
| BxPC-3 | 654.3 | Pancreatic cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.365G>A (p.Arg122His) | missense | 0.01% | Unknown functional effect; reported in ClinVar |
| c.487C>T (p.Arg163Trp) | missense | 0.005% | Unknown functional effect; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC for CELA3B.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity | • proteolysis |
| • extracellular space | • digestion |
| • pancreatic juice |
Pathways
• Protein digestion and absorption (Reactome: R-HSA-8963743)
• Degradation of extracellular matrix (Reactome: R-HSA-1474228)
Protein Summary
CELA3B is a serine protease synthesized as a zymogen in pancreatic acinar cells. Upon secretion into the duodenum, it is activated by trypsin cleavage. The active enzyme preferentially cleaves peptide bonds after alanine, valine, and other small hydrophobic residues, contributing to the digestion of dietary proteins. Its expression is largely restricted to the pancreas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CELA3B Knockout HEK293 Cell Line | EDJ-KQ8012 | Human | 23436 | Details Get a Quote |
| CELA3B Knockout HeLa Cell Line | EDJ-KQ55739 | Human | 23436 | Details Get a Quote |
| CELA3B Knockout A-549 Cell Line | EDJ-KQ64237 | Human | 23436 | Details Get a Quote |
| CELA3B Knockout HCT 116 Cell Line | EDJ-KQ72682 | Human | 23436 | Details Get a Quote |
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