CEACAM19
Carcinoembryonic Antigen Related Cell Adhesion Molecule 19
Gene Information Card
| Symbol | CEACAM19 |
|---|---|
| Full Name | Carcinoembryonic Antigen Related Cell Adhesion Molecule 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 56984 ncbi.nlm.nih.gov/gene/56984 |
| Ensembl ID | ENSG00000186567 |
| UniProt ID | Q7Z692 |
| OMIM ID | 617727 |
| HGNC ID | 18172 |
| Aliases | CEAL1, CEACAM19 |
Description
CEACAM19 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 19) is a protein-coding gene belonging to the carcinoembryonic antigen (CEA) family within the immunoglobulin superfamily. The encoded protein is a glycosylphosphatidylinositol (GPI)-anchored cell surface molecule involved in cell adhesion, migration, and signaling. CEACAM19 is expressed in various tissues and has been implicated in cancer progression, particularly in breast and lung cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of CEACAM19 may promote tumor cell proliferation and migration through activation of PI3K/Akt signaling. | PubMed: 25605247 |
| Lung Cancer | CEACAM19 is upregulated in non-small cell lung cancer and associated with poor prognosis, potentially via enhanced cell adhesion and invasion. | PubMed: 27806348 |
| Colorectal Cancer | Altered CEACAM19 expression may contribute to tumorigenesis through disruption of cell-cell adhesion. | PubMed: 29170764 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 5.2 nTPM | Medium |
| Lung | 3.8 nTPM | Low |
| Colon | 4.1 nTPM | Low |
| Stomach | 2.9 nTPM | Low |
| Prostate | 1.5 nTPM | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 6.0 nTPM | Moderate expression |
| A549 (lung cancer) | 4.5 nTPM | Low expression |
| HCT116 (colorectal cancer) | 3.2 nTPM | Low expression |
| HEK293 (embryonic kidney) | 1.0 nTPM | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.301G>A (p.Gly101Arg) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.487C>T (p.Pro163Ser) | Missense | <0.1% (COSMIC) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • GPI-anchor (GO:0016255) | • signal transduction (GO:0007165) |
Pathways
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Cell adhesion molecules (CAMs) (KEGG: hsa04514)
Protein Summary
CEACAM19 is a GPI-anchored cell surface glycoprotein of the CEA family. It mediates homophilic and heterophilic cell adhesion and modulates intracellular signaling pathways, including PI3K/Akt. The protein is implicated in cancer cell proliferation, migration, and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CEACAM19 Knockout HEK293 Cell Line | EDJ-KQ12853 | Human | 56971 | Details Get a Quote |
| CEACAM19 Knockout A-549 Cell Line | EDJ-KQ42011 | Human | 56971 | Details Get a Quote |
| CEACAM19 Knockout HCT 116 Cell Line | EDJ-KQ42012 | Human | 56971 | Details Get a Quote |
| CEACAM19 Knockout HeLa Cell Line | EDJ-KQ42013 | Human | 56971 | Details Get a Quote |
