CEACAM18
Carcinoembryonic Antigen Related Cell Adhesion Molecule 18
Gene Information Card
| Symbol | CEACAM18 |
|---|---|
| Full Name | Carcinoembryonic Antigen Related Cell Adhesion Molecule 18 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 145508 ncbi.nlm.nih.gov/gene/145508 |
| Ensembl ID | ENSG00000188290 |
| UniProt ID | Q6UY09 |
| OMIM ID | 616992 |
| HGNC ID | HGNC:24294 |
| Aliases | CEACAM18, CEACAM-18 |
Description
CEACAM18 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 18) is a protein-coding gene belonging to the CEACAM family within the immunoglobulin superfamily. It encodes a cell surface glycoprotein involved in cell adhesion, signaling, and immune regulation. The gene is located on chromosome 19q13.2 and is predominantly expressed in epithelial tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered CEACAM18 expression may contribute to tumor progression and metastasis through disrupted cell adhesion. | Limited evidence from expression profiling studies (COSMIC, NCBI). |
| Breast Cancer | Differential expression observed in tumor vs. normal tissue; functional role not fully elucidated. | Expression data from NCBI GEO and COSMIC. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 5.2 | Medium |
| Small Intestine | 3.8 | Low |
| Stomach | 2.1 | Low |
| Lung | 1.5 | Low |
| Breast | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HT-29 (Colorectal) | 4.7 | Moderate expression |
| MCF-7 (Breast) | 1.2 | Low expression |
| A549 (Lung) | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | 0.02% (COSMIC) | Unknown functional impact |
| c.456G>A | Synonymous | 0.01% (COSMIC) | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • protein binding (GO:0005515) |
Pathways
• Cell adhesion molecules (CAMs) - Homo sapiens (hsa04514)
Protein Summary
CEACAM18 is a single-pass type I membrane protein with an N-terminal immunoglobulin-like domain. It mediates homophilic and heterophilic cell-cell adhesion and may modulate immune responses. The protein is glycosylated and localized to the apical surface of epithelial cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CEACAM18 Knockout HEK293 Cell Line | EDJ-KQ12094 | Human | 729767 | Details Get a Quote |
| CEACAM18 Knockout HeLa Cell Line | EDJ-KQ60762 | Human | 729767 | Details Get a Quote |
| CEACAM18 Knockout A-549 Cell Line | EDJ-KQ69231 | Human | 729767 | Details Get a Quote |
| CEACAM18 Knockout HCT 116 Cell Line | EDJ-KQ77588 | Human | 729767 | Details Get a Quote |
