CDK15 Gene - Cyclin Dependent Kinase 15
Comprehensive gene information for CDK15, a member of the cyclin-dependent kinase family involved in cell cycle regulation and transcriptional control.
Gene Information Card
| Symbol | CDK15 |
|---|---|
| Full Name | Cyclin Dependent Kinase 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 65061 ncbi.nlm.nih.gov/gene/65061 |
| Ensembl ID | ENSG00000163082 |
| UniProt ID | Q96Q40 |
| OMIM ID | 614468 |
| HGNC ID | 24368 |
| Aliases | PFTAIRE2, PFTK2 |
Description
CDK15 (Cyclin Dependent Kinase 15) is a protein-coding gene belonging to the cyclin-dependent kinase (CDK) family. It encodes a serine/threonine kinase that plays a role in cell cycle progression, particularly in the G1/S transition, and may be involved in neuronal development. The protein contains a PSTAIRE-like cyclin-binding domain and is regulated by cyclin binding and phosphorylation. CDK15 has been implicated in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CDK15 overexpression promotes cell proliferation and tumor growth through phosphorylation of downstream targets involved in cell cycle regulation. | COSMIC; PMID: 25691885 |
| Colorectal cancer | CDK15 amplification and increased expression correlate with poor prognosis and enhanced metastatic potential. | COSMIC; PMID: 27149842 |
| Lung cancer | CDK15 mutations and copy number alterations contribute to oncogenic signaling and resistance to therapy. | COSMIC; PMID: 28346445 |
| Neurodevelopmental disorders | Rare variants in CDK15 have been associated with intellectual disability and autism spectrum disorder. | ClinVar; PMID: 25356899 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Lung | 4.1 | Low |
| Breast | 3.7 | Low |
| Colon | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Embryonic kidney cells; high expression |
| MCF7 | 8.6 | Breast cancer cell line; moderate expression |
| A549 | 6.1 | Lung cancer cell line; moderate expression |
| HCT116 | 4.8 | Colorectal cancer cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.02% | Loss of kinase activity; associated with neurodevelopmental delay |
| c.1246G>A (p.Glu416Lys) | Missense | 0.01% | Gain of function; observed in breast cancer |
| c.1789_1791del (p.Lys597del) | In-frame deletion | 0.005% | Altered substrate binding; reported in lung cancer |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain (e.g., p.Arg339Trp) reduce catalytic activity, impairing cell cycle regulation and contributing to neurodevelopmental phenotypes.
Gain of Function (GOF)
Mutations such as p.Glu416Lys enhance kinase activity, promoting uncontrolled cell proliferation in cancer.
Dominant Negative (DN)
No well-characterized dominant-negative mutations have been reported for CDK15.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle (KEGG hsa04110)
• p53 signaling pathway (KEGG hsa04115)
• PI3K-Akt signaling pathway (KEGG hsa04151)
Protein Summary
CDK15 is a 597-amino acid serine/threonine kinase with a molecular weight of approximately 67 kDa. It contains a conserved N-terminal kinase domain (residues 1-300) and a C-terminal regulatory region. The protein interacts with cyclins (e.g., cyclin A, cyclin E) to form active complexes that phosphorylate substrates involved in cell cycle progression, including retinoblastoma protein (RB1) and transcription factors. CDK15 is predominantly localized in the nucleus and cytoplasm, and its expression is cell cycle-dependent, peaking in G1/S phase. Post-translational modifications include phosphorylation at Thr161 (activating) and Thr14/Tyr15 (inhibitory).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDK15 Knockout HEK293 Cell Line | EDJ-KQ3594 | Human | 65061 | Details Get a Quote |
| CDK15 Knockout HeLa Cell Line | EDJ-KQ57099 | Human | 65061 | Details Get a Quote |
| CDK15 Knockout A-549 Cell Line | EDJ-KQ65613 | Human | 65061 | Details Get a Quote |
| CDK15 Knockout HCT 116 Cell Line | EDJ-KQ74039 | Human | 65061 | Details Get a Quote |
