CDK11B
Cyclin Dependent Kinase 11B
Gene Information Card
| Symbol | CDK11B |
|---|---|
| Full Name | Cyclin Dependent Kinase 11B |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 984 ncbi.nlm.nih.gov/gene/984 |
| Ensembl ID | ENSG00000108179 |
| UniProt ID | P21127 |
| OMIM ID | 603679 |
| HGNC ID | 1773 |
| Aliases | CDC2L2, CDK11-p110, CDK11-p58, PITSLRE |
Description
CDK11B encodes a member of the serine/threonine protein kinase family that is closely related to the cell division cycle 2 (CDC2)/cyclin-dependent kinase (CDK) subfamily. The protein is involved in cell cycle regulation, transcription, and RNA processing. Alternative splicing generates multiple transcript variants, including a large isoform (p110) and a smaller isoform (p58) that is expressed during G2/M phase. CDK11B is located on chromosome 1p36.33, a region frequently altered in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression and amplification of CDK11B contribute to tumor proliferation | COSMIC, ClinVar |
| Colorectal cancer | Altered expression linked to cell cycle dysregulation | COSMIC |
| Lung cancer | Mutations and copy number changes observed | COSMIC |
| Hepatocellular carcinoma | Upregulation associated with poor prognosis | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 11.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| K562 | 13.2 | Leukemia cell line |
| A549 | 11.8 | Lung cancer cell line |
| MCF7 | 10.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are classified as loss-of-function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • cell cycle | • mitotic cell cycle |
| • RNA splicing | • regulation of transcription by RNA polymerase II |
Pathways
• Cell Cycle
• Mitotic G1-G1/S phases
• RNA Polymerase II Transcription
Protein Summary
CDK11B is a serine/threonine kinase that regulates cell cycle progression, particularly at the G2/M transition, and participates in transcription and RNA processing. The protein contains a kinase domain and localizes to the nucleus. It interacts with cyclin L and other CDK-associated proteins. Alternative splicing produces isoforms with distinct functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDK11B Knockout HEK293 Cell Line | EDJ-KQ4231 | Human | 984 | Details Get a Quote |
| CDK11B Knockout A-549 Cell Line | EDJ-KQ26698 | Human | 984 | Details Get a Quote |
| CDK11B Knockout HCT 116 Cell Line | EDJ-KQ26699 | Human | 984 | Details Get a Quote |
| CDK11B Knockout HeLa Cell Line | EDJ-KQ26700 | Human | 984 | Details Get a Quote |
