CDK11A
Cyclin Dependent Kinase 11A, a key regulator of cell cycle and transcription
Gene Information Card
| Symbol | CDK11A |
|---|---|
| Full Name | cyclin dependent kinase 11A |
| Gene Type | protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 728642 ncbi.nlm.nih.gov/gene/728642 |
| Ensembl ID | ENSG00000213977 |
| UniProt ID | Q9UQ88 |
| OMIM ID | 605236 |
| HGNC ID | 1729 |
| Aliases | CDC2L2, CDK11-p110, CDK11-p58, PITSLRE |
Description
CDK11A (cyclin dependent kinase 11A) is a protein-coding gene that belongs to the cyclin-dependent kinase (CDK) family. It encodes a serine/threonine protein kinase that plays critical roles in cell cycle regulation, particularly during the G2/M phase, and in transcriptional regulation. The gene produces multiple isoforms through alternative splicing, including a larger 110 kDa form (CDK11-p110) involved in transcription and RNA processing, and a smaller 58 kDa form (CDK11-p58) that is activated during mitosis. CDK11A is located on chromosome 1p36.33, a region frequently altered in cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of CDK11A expression and mutations contribute to uncontrolled cell proliferation and genomic instability. | COSMIC; ClinVar |
| Neurodevelopmental disorders | Rare variants in CDK11A have been implicated in intellectual disability and developmental delay. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 10.5 | Medium |
| Bone marrow | 9.8 | Medium |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.0 | Cervical cancer cell line |
| K562 | 11.5 | Leukemia cell line |
| A549 | 9.2 | Lung cancer cell line |
| MCF7 | 8.7 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation of the kinase domain |
| c.567G>A (p.Gly189Arg) | Missense | <0.1% | Unknown; predicted damaging by in silico tools |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are likely loss-of-function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • cell cycle | • mitotic cell cycle |
| • transcription | • DNA-templated |
| • RNA processing |
Pathways
• Cell Cycle
• Mitotic
• Transcriptional regulation by CDK11
Protein Summary
The CDK11A protein is a serine/threonine kinase with two major isoforms: CDK11-p110 (110 kDa) and CDK11-p58 (58 kDa). CDK11-p110 is ubiquitously expressed and involved in transcriptional elongation and RNA splicing, while CDK11-p58 is specifically expressed during mitosis and regulates centrosome maturation and spindle formation. The protein contains a conserved kinase domain and a PITSLRE motif characteristic of CDK family members. Its activity is regulated by binding to cyclin L1 or L2.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDK11A Knockout HEK293 Cell Line | EDJ-KQ12844 | Human | 728642 | Details Get a Quote |
| CDK11A Knockout A-549 Cell Line | EDJ-KQ41995 | Human | 728642 | Details Get a Quote |
| CDK11A Knockout HCT 116 Cell Line | EDJ-KQ41996 | Human | 728642 | Details Get a Quote |
| CDK11A Knockout HeLa Cell Line | EDJ-KQ41997 | Human | 728642 | Details Get a Quote |
