CDH20 (Cadherin 20)
A type II classical cadherin involved in cell adhesion and potential tumor suppression.
Gene Information Card
| Symbol | CDH20 |
|---|---|
| Full Name | Cadherin 20 |
| Gene Type | Protein-coding |
| Chromosomal Location | 18q22.1 |
| NCBI Gene ID | 28316 ncbi.nlm.nih.gov/gene/28316 |
| Ensembl ID | ENSG00000101558 |
| UniProt ID | Q9HBT6 |
| OMIM ID | 605807 |
| HGNC ID | 1753 |
| Aliases | CDH7, CDH20L, cadherin-20 |
Description
CDH20 (cadherin 20) is a member of the cadherin superfamily of calcium-dependent cell adhesion molecules. It encodes a type II classical cadherin, predominantly expressed in the brain and involved in neural development and synaptic organization. CDH20 has been implicated in tumor suppression, with reduced expression observed in various cancers, and its loss may contribute to metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Downregulation of CDH20 is associated with increased invasiveness and poor prognosis. | PMID: 25656852 |
| Colorectal cancer | Hypermethylation of CDH20 promoter leads to silencing and correlates with metastasis. | PMID: 28723891 |
| Breast cancer | Loss of CDH20 expression promotes epithelial-mesenchymal transition (EMT). | PMID: 30356049 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 3.2 | Low |
| Lung | 1.8 | Low |
| Kidney | 1.1 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 8.4 | Neuronal lineage |
| MCF7 (breast cancer) | 0.9 | Low expression |
| HCT116 (colorectal) | 1.2 | Low expression |
| A549 (lung cancer) | 0.6 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Truncation, loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Premature stop, loss of function |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg412*, p.Trp189*) result in truncated proteins lacking transmembrane and cytoplasmic domains, leading to loss of adhesive function.
Gain of Function (GOF)
No gain-of-function mutations reported for CDH20.
Dominant Negative (DN)
No dominant-negative mutations characterized for CDH20.
View complete mutation data：
Gene Ontology (GO)
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • calcium ion binding (GO:0005509) |
| • membrane (GO:0016020) | • plasma membrane (GO:0005886) |
| • cell-cell junction (GO:0005913) |
Pathways
• Cell adhesion molecules (CAMs) – KEGG hsa04514
• Adherens junction – KEGG hsa04520
• Wnt signaling pathway – KEGG hsa04310 (indirect)
Protein Summary
Cadherin 20 is a 796-amino acid type II classical cadherin with an extracellular domain containing 5 cadherin repeats, a single transmembrane domain, and a cytoplasmic tail that interacts with catenins. It mediates calcium-dependent homophilic cell-cell adhesion, particularly in neural tissues. The protein is implicated in maintaining tissue architecture and suppressing tumor invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDH20 Knockout HEK293 Cell Line | EDJ-KQ8857 | Human | 28316 | Details Get a Quote |
| PCDH20 Knockout HEK293 Cell Line | EDJ-KQ51634 | Human | 64881 | Details Get a Quote |
| CDH20 Knockout HeLa Cell Line | EDJ-KQ56072 | Human | 28316 | Details Get a Quote |
| PCDH20 Knockout HeLa Cell Line | EDJ-KQ57091 | Human | 64881 | Details Get a Quote |
| CDH20 Knockout A-549 Cell Line | EDJ-KQ64556 | Human | 28316 | Details Get a Quote |
| PCDH20 Knockout A-549 Cell Line | EDJ-KQ65603 | Human | 64881 | Details Get a Quote |
| CDH20 Knockout HCT 116 Cell Line | EDJ-KQ73014 | Human | 28316 | Details Get a Quote |
| PCDH20 Knockout HCT 116 Cell Line | EDJ-KQ74031 | Human | 64881 | Details Get a Quote |
Displaying Records 1 To 8 Of 8 Records
