CDCA7L: Cell Division Cycle Associated 7 Like
A multifunctional protein involved in transcriptional regulation, cell cycle control, and MYC-mediated oncogenesis.
Gene Information Card
| Symbol | CDCA7L |
|---|---|
| Full Name | Cell Division Cycle Associated 7 Like |
| Gene Type | Protein coding |
| Chromosomal Location | 7p15.3 |
| NCBI Gene ID | 55536 ncbi.nlm.nih.gov/gene/55536 |
| Ensembl ID | ENSG00000106462 |
| UniProt ID | Q9BWT1 |
| OMIM ID | 609685 |
| HGNC ID | 30716 |
| Aliases | JPO2, R1, RAM2, bA325O19.4 |
Description
CDCA7L (Cell Division Cycle Associated 7 Like) is a protein-coding gene that encodes a nuclear protein involved in transcriptional regulation and cell cycle progression. It interacts with MYC and other transcription factors to modulate gene expression, and has been implicated in cellular proliferation, differentiation, and oncogenesis. The protein contains a PHD finger domain and is thought to function as a transcriptional cofactor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | CDCA7L is overexpressed in several cancers and may promote MYC-mediated transformation by enhancing transcriptional activity. | COSMIC, NCBI Gene |
| Neuroblastoma | CDCA7L expression correlates with MYCN amplification and poor prognosis. | PubMed, NCBI Gene |
| Lung cancer | Upregulation of CDCA7L contributes to cell proliferation and invasion. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 6.9 | Low |
| Brain | 5.1 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Embryonic kidney cell line |
| HeLa | 12.1 | Cervical cancer cell line |
| A549 | 10.5 | Lung carcinoma cell line |
| K562 | 9.8 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.632A>G (p.Asn211Ser) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CDCA7L.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role in oncogenesis.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • transcription coactivator activity | • protein binding |
| • nucleus | • chromatin binding |
| • cell cycle | • regulation of transcription by RNA polymerase II |
Pathways
• MYC transcriptional activation
• Cell cycle
Protein Summary
The CDCA7L protein (UniProt Q9BWT1) is a 410-amino acid nuclear protein containing a PHD finger domain. It functions as a transcriptional cofactor, interacting with MYC and other proteins to regulate gene expression involved in cell proliferation and differentiation. The protein is expressed in multiple tissues and is upregulated in various cancers, suggesting a role in tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDCA7L Knockout HEK293 Cell Line | EDJ-KQ12081 | Human | 55536 | Details Get a Quote |
| CDCA7L Knockout A-549 Cell Line | EDJ-KQ41984 | Human | 55536 | Details Get a Quote |
| CDCA7L Knockout HCT 116 Cell Line | EDJ-KQ41986 | Human | 55536 | Details Get a Quote |
| CDCA7L Knockout HeLa Cell Line | EDJ-KQ41987 | Human | 55536 | Details Get a Quote |
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