CDC7 Cell Division Cycle 7
A key serine/threonine kinase regulating DNA replication initiation and cell cycle progression
Gene Information Card
| Symbol | CDC7 |
|---|---|
| Full Name | Cell division cycle 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p22.1 |
| NCBI Gene ID | 8317 ncbi.nlm.nih.gov/gene/8317 |
| Ensembl ID | ENSG00000097046 |
| UniProt ID | O00311 |
| OMIM ID | 603311 |
| HGNC ID | 1745 |
| Aliases | CDC7L1, HsCDC7, huCDC7, CDC7-related kinase |
Description
CDC7 encodes a serine/threonine kinase that is essential for the initiation of DNA replication. It forms a complex with DBF4 (ASK) and phosphorylates the MCM2-7 complex, promoting origin firing and cell cycle progression. CDC7 activity is tightly regulated during the cell cycle and is critical for S-phase entry. Dysregulation of CDC7 is implicated in various cancers and genomic instability.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression of CDC7 promotes uncontrolled cell proliferation | COSMIC, NCBI |
| Breast cancer | CDC7 amplification and overexpression correlate with poor prognosis | COSMIC, ClinVar |
| Lung cancer | CDC7 upregulation associated with tumor progression and metastasis | COSMIC |
| Ovarian cancer | CDC7 overexpression linked to chemoresistance | COSMIC |
| Hepatocellular carcinoma | CDC7 overexpression drives hepatocarcinogenesis | NCBI, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 18.5 | High |
| Bone marrow | 12.3 | Medium |
| Lymph node | 10.1 | Medium |
| Spleen | 9.8 | Medium |
| Brain | 4.2 | Low |
| Heart | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| HEK293 | 12.8 | Embryonic kidney |
| MCF7 | 11.5 | Breast cancer cell line |
| A549 | 10.9 | Lung cancer cell line |
| HCT116 | 14.1 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Loss of start codon, likely loss of function |
| c.154C>T (p.Arg52Trp) | Missense | <0.1% | Unknown significance |
| c.1066G>A (p.Glu356Lys) | Missense | <0.1% | Unknown significance |
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Met1?) may abolish protein expression or kinase activity, impairing DNA replication.
Gain of Function (GOF)
Not well documented; overexpression is more common in cancer.
Dominant Negative (DN)
No dominant-negative mutations reported in CDC7.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell cycle (KEGG hsa04110)
• DNA replication (KEGG hsa03030)
• Activation of the pre-replicative complex (Reactome R-HSA-68962)
Protein Summary
CDC7 is a 574-amino acid serine/threonine kinase with a catalytic domain in the N-terminal region. It interacts with DBF4/ASK to form an active complex that phosphorylates MCM proteins, licensing origins of replication. The protein is localized to the nucleus and its expression peaks in S phase. CDC7 activity is essential for cell proliferation and is frequently upregulated in cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC78 Knockout HEK293 Cell Line | EDJ-KQ8448 | Human | 124093 | Details Get a Quote |
| CCDC7 Knockout HEK293 Cell Line | EDJ-KQ8790 | Human | 79741 | Details Get a Quote |
| CCDC70 Knockout HEK293 Cell Line | EDJ-KQ9842 | Human | 83446 | Details Get a Quote |
| CCDC77 Knockout HEK293 Cell Line | EDJ-KQ10066 | Human | 84318 | Details Get a Quote |
| CCDC74A Knockout HEK293 Cell Line | EDJ-KQ10615 | Human | 90557 | Details Get a Quote |
| CCDC74B Knockout HEK293 Cell Line | EDJ-KQ10731 | Human | 91409 | Details Get a Quote |
| CCDC71 Knockout HEK293 Cell Line | EDJ-KQ12761 | Human | 64925 | Details Get a Quote |
| CCDC71L Knockout HEK293 Cell Line | EDJ-KQ12762 | Human | 168455 | Details Get a Quote |
| CCDC73 Knockout HEK293 Cell Line | EDJ-KQ12763 | Human | 493860 | Details Get a Quote |
| CCDC7 Knockout A-549 Cell Line | EDJ-KQ35070 | Human | 79741 | Details Get a Quote |
| CCDC7 Knockout HCT 116 Cell Line | EDJ-KQ35071 | Human | 79741 | Details Get a Quote |
| CCDC7 Knockout HeLa Cell Line | EDJ-KQ35072 | Human | 79741 | Details Get a Quote |
| CCDC77 Knockout A-549 Cell Line | EDJ-KQ37114 | Human | 84318 | Details Get a Quote |
| CCDC77 Knockout HCT 116 Cell Line | EDJ-KQ37115 | Human | 84318 | Details Get a Quote |
| CCDC77 Knockout HeLa Cell Line | EDJ-KQ37116 | Human | 84318 | Details Get a Quote |
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