CDC42 Gene – Cell Division Cycle 42 | NCBI, UniProt, OMIM, ClinVar

CDC42 (Cell Division Cycle 42) is a small GTPase of the Rho family that regulates cell polarity, cytoskeletal organization, cell migration, and signal transduction. It cycles between an active GTP-bound and inactive GDP-bound state, acting as a molecular switch. CDC42 is involved in multiple cellular processes including cell cycle progression, vesicle trafficking, and transcriptional regulation. Dysregulation of CDC42 is implicated in various cancers, developmental disorders, and immune deficiencies.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Rho GTPase cycle (Reactome: R-HSA-194840)

• Signaling by Rho family GTPases (Reactome: R-HSA-194315)

• CDC42 signaling events (PID: cdc42pathway)

• Regulation of actin dynamics for phagocytic cup formation (Reactome: R-HSA-2029480)

CDC42 encodes a 191-amino acid small GTPase (UniProt P60953) that localizes to the plasma membrane and intracellular vesicles. The protein contains a conserved GTP-binding domain and a C-terminal CAAX motif for prenylation. It interacts with numerous effectors including PAK kinases, WASP, and IQGAP to regulate actin polymerization, cell polarity, and vesicle trafficking. Post-translational modifications such as phosphorylation and ubiquitination modulate its activity and stability.