CDC34 Gene - Cell Division Cycle 34
Ubiquitin-Conjugating Enzyme E2 R1
Gene Information Card
| Symbol | CDC34 |
|---|---|
| Full Name | Cell Division Cycle 34 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 997 ncbi.nlm.nih.gov/gene/997 |
| Ensembl ID | ENSG00000100030 |
| UniProt ID | P49427 |
| OMIM ID | 603272 |
| HGNC ID | 1739 |
| Aliases | UBC3, E2-CDC34, UBCH3 |
Description
CDC34 encodes a member of the ubiquitin-conjugating enzyme (E2) family. The encoded protein is required for the G1 to S phase transition of the cell cycle and targets proteins for degradation via the ubiquitin-proteasome pathway. It specifically interacts with the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex to ubiquitinate substrates such as cyclin-dependent kinase inhibitors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Dysregulation of CDC34 expression or activity alters ubiquitination of cell cycle regulators, promoting uncontrolled proliferation | COSMIC, NCBI |
| Fanconi Anemia (complementation group) | Potential role in DNA repair pathways; altered CDC34 function may impair ubiquitin signaling | OMIM, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 15.2 | Medium |
| Brain | 10.8 | Medium |
| Liver | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 22.1 | High expression |
| HeLa | 18.7 | High expression |
| K562 | 12.4 | Medium expression |
| MCF7 | 9.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.214C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein; reduced ubiquitination activity.
Gain of Function (GOF)
Not well documented; overexpression linked to oncogenesis.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin conjugating enzyme activity | • protein ubiquitination |
| • cell cycle G1/S transition | • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
Pathways
• Ubiquitin mediated proteolysis
• Cell cycle - G1/S transition
• SCF complex assembly
Protein Summary
CDC34 is a 236-amino acid ubiquitin-conjugating enzyme (E2) that catalyzes the transfer of ubiquitin from an E1 enzyme to specific substrates in conjunction with an E3 ligase. It plays a critical role in cell cycle progression by targeting cyclin-dependent kinase inhibitors (e.g., p27Kip1) for degradation. The protein contains a conserved active site cysteine (Cys93) required for ubiquitin thioester formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDC34 Knockout HEK293 Cell Line | EDJ-KQ3544 | Human | 997 | Details Get a Quote |
| CDC34 Knockout A-549 Cell Line | EDJ-KQ26706 | Human | 997 | Details Get a Quote |
| CDC34 Knockout HCT 116 Cell Line | EDJ-KQ26707 | Human | 997 | Details Get a Quote |
| CDC34 Knockout HeLa Cell Line | EDJ-KQ26708 | Human | 997 | Details Get a Quote |
