CDC20: Cell Division Cycle 20 Homolog
Key regulator of the anaphase-promoting complex/cyclosome (APC/C) and mitotic exit
Gene Information Card
| Symbol | CDC20 |
|---|---|
| Full Name | Cell Division Cycle 20 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1p34.2 |
| NCBI Gene ID | 991 ncbi.nlm.nih.gov/gene/991 |
| Ensembl ID | ENSG00000119912 |
| UniProt ID | Q12834 |
| OMIM ID | 603618 |
| HGNC ID | 1723 |
| Aliases | CDC20A, p55CDC, bA276H19.3 |
Description
CDC20 encodes a cell cycle protein that acts as a regulatory subunit and activator of the anaphase-promoting complex/cyclosome (APC/C). It is essential for the metaphase-to-anaphase transition by targeting securin and cyclin B1 for degradation. CDC20 also functions in the spindle assembly checkpoint (SAC) by binding to MAD2 and BUBR1. Overexpression is frequently observed in various cancers and correlates with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | CDC20 overexpression promotes aneuploidy and tumor progression | PMID: 25605247 |
| Breast cancer | High CDC20 expression associated with poor survival and chemoresistance | PMID: 28925394 |
| Lung cancer | CDC20 upregulation drives cell proliferation via APC/C activation | PMID: 30093503 |
| Prostate cancer | CDC20 amplification linked to aggressive disease | PMID: 31085178 |
| Gastric cancer | CDC20 overexpression correlates with lymph node metastasis | PMID: 27573518 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 38.5 | High |
| Bone marrow | 25.2 | High |
| Lymph node | 18.7 | Medium |
| Colon | 12.3 | Medium |
| Breast | 8.1 | Low |
| Lung | 6.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 45.2 | Cervical cancer cell line |
| HEK293 | 32.1 | Embryonic kidney |
| MCF7 | 28.7 | Breast cancer |
| A549 | 22.5 | Lung cancer |
| HCT116 | 19.8 | Colorectal cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential start loss |
| c.485C>T | Missense | <0.01% | p.Thr162Ile; rare variant |
| c.1066G>A | Missense | <0.01% | p.Glu356Lys; uncertain significance |
| c.1372C>T | Nonsense | <0.01% | p.Arg458*; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein; rare in tumors.
Gain of Function (GOF)
Overexpression (not mutation) is the predominant mechanism; no recurrent activating mutations reported.
Dominant Negative (DN)
Not described for CDC20; dominant-negative effects are not established.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle (KEGG hsa04110)
• Oocyte meiosis (KEGG hsa04114)
• Ubiquitin mediated proteolysis (KEGG hsa04120)
• APC/C-mediated degradation of cell cycle proteins (Reactome R-HSA-174178)
Protein Summary
CDC20 is a 55 kDa protein containing seven WD40 repeats that form a beta-propeller structure. It binds to the APC/C via its C-terminal IR tail and activates the complex by recruiting substrates such as securin and cyclin B1. CDC20 is tightly regulated by phosphorylation and by the spindle assembly checkpoint proteins MAD2 and BUBR1. Its overexpression in cancers promotes chromosomal instability and resistance to anti-mitotic drugs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC200 Knockout HEK293 Cell Line | EDJ-KQ12810 | Human | 100874261 | Details Get a Quote |
| CCDC201 Knockout HEK293 Cell Line | EDJ-KQ12812 | Human | 114515518 | Details Get a Quote |
| CDC20B Knockout HEK293 Cell Line | EDJ-KQ12835 | Human | 166979 | Details Get a Quote |
| CCDC200 Knockout HeLa Cell Line | EDJ-KQ41943 | Human | 100874261 | Details Get a Quote |
| CCDC201 Knockout A-549 Cell Line | EDJ-KQ41944 | Human | 114515518 | Details Get a Quote |
| CCDC201 Knockout HCT 116 Cell Line | EDJ-KQ41945 | Human | 114515518 | Details Get a Quote |
| CCDC201 Knockout HeLa Cell Line | EDJ-KQ41946 | Human | 114515518 | Details Get a Quote |
| CCDC200 Knockout HCT 116 Cell Line | EDJ-KQ40694 | Human | 100874261 | Details Get a Quote |
| CDC20B Knockout HeLa Cell Line | EDJ-KQ58900 | Human | 166979 | Details Get a Quote |
| CDC20B Knockout A-549 Cell Line | EDJ-KQ67389 | Human | 166979 | Details Get a Quote |
| CDC20B Knockout HCT 116 Cell Line | EDJ-KQ75782 | Human | 166979 | Details Get a Quote |
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