CD300LF: Immune Receptor Modulating Phagocytosis and Inflammation
A comprehensive guide to CD300LF gene, protein, and associated diseases
Gene Information Card
| Symbol | CD300LF |
|---|---|
| Full Name | CD300 molecule-like family member F |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.1 |
| NCBI Gene ID | 146722 ncbi.nlm.nih.gov/gene/146722 |
| Ensembl ID | ENSG00000187486 |
| UniProt ID | Q8N6N3 |
| OMIM ID | 617870 |
| HGNC ID | 26717 |
| Aliases | CMRF-35, IREM-1, CD300f, LMIR3, CLM-1 |
Description
CD300LF (CD300 molecule-like family member F) encodes a transmembrane immune receptor belonging to the CD300 family. It is expressed on myeloid cells and modulates phagocytosis, inflammatory responses, and cell survival through ITIM and ITSM motifs. The protein binds phosphatidylserine and phosphatidylethanolamine, acting as a sensor for apoptotic cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | CD300LF polymorphisms may alter clearance of apoptotic cells, promoting autoimmunity | PMID: 25605271 |
| Rheumatoid arthritis | Dysregulated CD300LF expression on macrophages contributes to chronic inflammation | PMID: 27434027 |
| Cancer (colorectal, gastric) | Loss of CD300LF expression reduces immune surveillance and promotes tumor growth | PMID: 29150432 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Liver | 6.1 | Low |
| Whole blood | 4.2 | Low |
| Bone marrow | 15.0 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Monocytes (THP-1) | 18.0 | High expression |
| Macrophages (differentiated) | 22.5 | Upregulated upon activation |
| B lymphocytes (Raji) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.421C>T (p.Arg141Trp) | Missense | 0.01% (gnomAD) | May impair ligand binding |
| c.763G>A (p.Gly255Ser) | Missense | 0.005% (gnomAD) | Unknown functional effect |
| c.1000_1001insA | Frameshift | <0.001% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants that truncate the protein or disrupt ITIM/ITSM motifs reduce inhibitory signaling and phagocytosis.
Gain of Function (GOF)
Not reported in literature or curated databases.
Dominant Negative (DN)
Not reported; CD300LF functions as a monomeric receptor.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Phagocytosis (R-HSA-2029480)
• Immune System (R-HSA-168256)
• Apoptotic cell clearance (R-HSA-2029485)
Protein Summary
CD300LF is a 299-amino acid type I transmembrane protein with an extracellular Ig-like domain, a transmembrane region, and a cytoplasmic tail containing ITIM and ITSM motifs. It binds phosphatidylserine and phosphatidylethanolamine on apoptotic cells, mediating their clearance by macrophages. The protein also modulates inflammatory cytokine production and inhibits NK cell cytotoxicity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD300LF Knockout HEK293 Cell Line | EDJ-KQ10491 | Human | 146722 | Details Get a Quote |
| CD300LF Knockout HeLa Cell Line | EDJ-KQ58552 | Human | 146722 | Details Get a Quote |
| CD300LF Knockout A-549 Cell Line | EDJ-KQ67042 | Human | 146722 | Details Get a Quote |
| CD300LF Knockout HCT 116 Cell Line | EDJ-KQ75443 | Human | 146722 | Details Get a Quote |
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