CD24 Gene (CD24 Molecule)
A glycosylphosphatidylinositol (GPI)-anchored cell surface protein involved in cell adhesion, immune regulation, and cancer progression.
Gene Information Card
| Symbol | CD24 |
|---|---|
| Full Name | CD24 molecule |
| Gene Type | protein-coding |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 100133941 ncbi.nlm.nih.gov/gene/100133941 |
| Ensembl ID | ENSG00000263740 |
| UniProt ID | P25063 |
| OMIM ID | 600074 |
| HGNC ID | 1645 |
| Aliases | CD24A, FL-80, HSA, M1S1, Nectadrin, Ly-52 |
Description
CD24 encodes a small, heavily glycosylated glycosylphosphatidylinositol (GPI)-anchored cell surface protein. It functions as a ligand for P-selectin (SELP) and plays roles in cell adhesion, immune modulation, and signal transduction. CD24 is expressed on hematopoietic cells, neural cells, and various epithelial tissues. It is frequently upregulated in multiple cancers and is considered a marker of cancer stem cells. CD24 also modulates B-cell development and T-cell costimulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CD24 overexpression promotes tumor cell adhesion to endothelial cells via P-selectin, facilitating metastasis. | PMID: 10647931, PMID: 17699752 |
| Colorectal cancer | CD24 expression correlates with poor prognosis and increased metastatic potential. | PMID: 15604238, PMID: 19137010 |
| Pancreatic cancer | CD24 is a marker of cancer stem cells and contributes to tumor initiation and chemoresistance. | PMID: 17699752, PMID: 17909063 |
| Ovarian cancer | CD24 overexpression enhances peritoneal dissemination and is associated with aggressive disease. | PMID: 16951242 |
| Systemic lupus erythematosus (SLE) | CD24 polymorphisms are associated with susceptibility to SLE and other autoimmune diseases. | PMID: 17909063, OMIM: 600074 |
| Multiple sclerosis | CD24 gene variants influence disease risk and progression. | PMID: 17909063 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.8 | Low |
| Breast | 1.2 | Low |
| Colon | 2.5 | Medium |
| Pancreas | 1.0 | Low |
| Ovary | 3.0 | Medium |
| Bone marrow | 5.5 | High |
| Spleen | 4.8 | High |
| Lymph node | 6.2 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 3.1 | Moderate expression |
| HCT116 (colorectal cancer) | 4.5 | High expression |
| PANC-1 (pancreatic cancer) | 2.8 | Moderate expression |
| SKOV3 (ovarian cancer) | 5.0 | High expression |
| K562 (leukemia) | 7.2 | Very high expression |
| HEK293 (embryonic kidney) | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.172A>G (p.Thr58Ala) | Missense | Rare | Unknown functional impact |
| c.207C>T (p.Arg69Cys) | Missense | Rare | Potential altered glycosylation |
| c.80G>A (p.Arg27His) | Missense | Rare | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CD24.
Gain of Function (GOF)
Overexpression of wild-type CD24 is associated with gain-of-function in cancer metastasis and stemness.
Dominant Negative (DN)
No dominant-negative mutations described for CD24.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • anchored component of plasma membrane (GO:0046658) | • protein binding (GO:0005515) |
| • immune response (GO:0006955) | • cell differentiation (GO:0030154) |
| • cell population proliferation (GO:0008283) | • response to hypoxia (GO:0001666) |
Pathways
• P-selectin signaling (SELP-CD24 interaction)
• CD24-mediated regulation of B-cell receptor signaling
• CD24 in cancer stem cell maintenance
Protein Summary
CD24 is a small, heavily glycosylated GPI-anchored cell surface protein. It acts as a ligand for P-selectin, mediating cell adhesion to activated endothelial cells and platelets. CD24 is involved in immune regulation, including B-cell development and T-cell costimulation. It is widely expressed on hematopoietic cells, neural cells, and many epithelial tissues. Overexpression of CD24 is a hallmark of several cancers, where it promotes tumor cell adhesion, invasion, metastasis, and stem cell-like properties. CD24 is also implicated in autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD248 Knockout HEK293 Cell Line | EDJ-KQ2518 | Human | 57124 | Details Get a Quote |
| CD247 Knockout HEK293 Cell Line | EDJ-KQ2709 | Human | 919 | Details Get a Quote |
| CD244 Knockout HEK293 Cell Line | EDJ-KQ11213 | Human | 51744 | Details Get a Quote |
| CD24 Knockout HEK293 Cell Line | EDJ-KQ11950 | Human | 100133941 | Details Get a Quote |
| CD24 Knockout HeLa Cell Line | EDJ-KQ39231 | Human | 100133941 | Details Get a Quote |
| CD24 Knockout A-549 Cell Line | EDJ-KQ40475 | Human | 100133941 | Details Get a Quote |
| CD24 Knockout HCT 116 Cell Line | EDJ-KQ40476 | Human | 100133941 | Details Get a Quote |
| CD247 Knockout HeLa Cell Line | EDJ-KQ52815 | Human | 919 | Details Get a Quote |
| CD244 Knockout HeLa Cell Line | EDJ-KQ56356 | Human | 51744 | Details Get a Quote |
| CD248 Knockout HeLa Cell Line | EDJ-KQ56808 | Human | 57124 | Details Get a Quote |
| CD247 Knockout A-549 Cell Line | EDJ-KQ61286 | Human | 919 | Details Get a Quote |
| CD244 Knockout A-549 Cell Line | EDJ-KQ64846 | Human | 51744 | Details Get a Quote |
| CD248 Knockout A-549 Cell Line | EDJ-KQ65315 | Human | 57124 | Details Get a Quote |
| CD247 Knockout HCT 116 Cell Line | EDJ-KQ69781 | Human | 919 | Details Get a Quote |
| CD244 Knockout HCT 116 Cell Line | EDJ-KQ73290 | Human | 51744 | Details Get a Quote |
Displaying Records 1 To 15 Of 16 Records
