CD209: Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
C-type lectin receptor involved in pathogen recognition and immune regulation
Gene Information Card
| Symbol | CD209 |
|---|---|
| Full Name | CD209 molecule |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 30835 ncbi.nlm.nih.gov/gene/30835 |
| Ensembl ID | ENSG00000090659 |
| UniProt ID | Q9NNX6 |
| OMIM ID | 604672 |
| HGNC ID | 1641 |
| Aliases | DC-SIGN, CDSIGN, CLEC4L |
Description
The CD209 gene encodes the dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN), a C-type lectin receptor expressed on the surface of dendritic cells and macrophages. DC-SIGN recognizes high-mannose carbohydrates on pathogens and endogenous glycoproteins, mediating pathogen capture, antigen presentation, and immune cell adhesion. It is notably exploited by HIV-1 for trans-infection of T cells and is involved in the recognition of multiple viruses, bacteria, and parasites.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 infection | DC-SIGN binds HIV-1 gp120 and facilitates trans-infection of CD4+ T cells | NCBI Gene, UniProt |
| Dengue virus infection | DC-SIGN mediates dengue virus entry into dendritic cells | UniProt, OMIM |
| Tuberculosis | DC-SIGN recognizes Mycobacterium tuberculosis mannosylated lipoarabinomannan | NCBI Gene, UniProt |
| SARS-CoV-2 infection | DC-SIGN binds spike glycoprotein and may enhance viral entry | UniProt |
| Aspergillosis | DC-SIGN binds Aspergillus fumigatus conidia | UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 15.2 | Medium |
| Spleen | 12.8 | Medium |
| Lung | 8.5 | Low |
| Small intestine | 6.1 | Low |
| Bone marrow | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 0.0 | Undetectable; induced upon differentiation |
| MUTZ-3 (dendritic cell line) | 25.0 | High expression |
| KG-1 (myeloid leukemia) | 0.0 | No expression |
| HL-60 (promyeloblast) | 0.0 | No expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs735239 (promoter variant) | SNP | 0.15 (global) | Associated with altered DC-SIGN expression and HIV-1 susceptibility |
| rs2287886 (promoter variant) | SNP | 0.20 (global) | Linked to dengue fever severity |
| p.Arg198Gln | Missense | Rare | Reduced binding to ICAM-3 |
Mutation functional classification
Loss of Function (LOF)
p.Arg198Gln reduces ICAM-3 binding and pathogen recognition
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • mannose binding (GO:0005529) | • receptor activity (GO:0004872) |
| • cell adhesion (GO:0007155) | • endocytosis (GO:0006897) |
| • innate immune response (GO:0045087) | • plasma membrane (GO:0005886) |
Pathways
• HIV-1 trans-infection pathway
• C-type lectin receptor signaling pathway
• Pathogen recognition and phagocytosis
Protein Summary
DC-SIGN is a type II transmembrane C-type lectin with a carbohydrate recognition domain (CRD) that binds mannose- and fucose-containing glycans. It forms tetramers on the cell surface, enhancing avidity for multivalent ligands. The protein mediates pathogen capture, antigen processing, and immune synapse formation. Its cytoplasmic tail contains internalization motifs for endocytosis and signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD209 Knockout HEK293 Cell Line | EDJ-KQ3776 | Human | 30835 | Details Get a Quote |
| CD209 Knockout HeLa Cell Line | EDJ-KQ56156 | Human | 30835 | Details Get a Quote |
| CD209 Knockout A-549 Cell Line | EDJ-KQ64646 | Human | 30835 | Details Get a Quote |
| CD209 Knockout HCT 116 Cell Line | EDJ-KQ73093 | Human | 30835 | Details Get a Quote |
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