CD200R1L Gene
CD200 Receptor 1 Like
Gene Information Card
| Symbol | CD200R1L |
|---|---|
| Full Name | CD200 receptor 1 like |
| Gene Type | protein-coding |
| Chromosomal Location | 3q13.2 |
| NCBI Gene ID | 344807 ncbi.nlm.nih.gov/gene/344807 |
| Ensembl ID | ENSG00000186185 |
| UniProt ID | Q6Q8B3 |
| OMIM ID | 617826 |
| HGNC ID | 24235 |
| Aliases | CD200R1L, CD200RLa, MGC138290 |
Description
CD200R1L (CD200 receptor 1 like) is a protein-coding gene that encodes a member of the immunoglobulin superfamily. The encoded protein is a receptor for CD200 and is involved in immune regulation, particularly in modulating myeloid cell activity. It is expressed in various immune tissues and cell types.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.6 | Low |
| Spleen | 0.4 | Low |
| Bone marrow | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 0.5 | Monocytic cell line |
| U937 | 0.4 | Histiocytic lymphoma |
| K562 | 0.2 | Chronic myeloid leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • transmembrane signaling receptor activity (GO:0004888) | • signal transduction (GO:0007165) |
| • plasma membrane (GO:0005886) |
Pathways
• CD200 receptor signaling (Reactome: R-HSA-1236974)
Protein Summary
The CD200R1L protein is a single-pass type I membrane protein belonging to the CD200 receptor family. It contains two immunoglobulin-like domains and a cytoplasmic tail with signaling motifs. It binds CD200 and modulates immune responses, particularly in macrophages and dendritic cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD200R1L Knockout HEK293 Cell Line | EDJ-KQ12829 | Human | 344807 | Details Get a Quote |
| CD200R1L Knockout HeLa Cell Line | EDJ-KQ59778 | Human | 344807 | Details Get a Quote |
| CD200R1L Knockout A-549 Cell Line | EDJ-KQ68247 | Human | 344807 | Details Get a Quote |
| CD200R1L Knockout HCT 116 Cell Line | EDJ-KQ76623 | Human | 344807 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
