CD200 Gene (OX-2 Membrane Glycoprotein)
Immune checkpoint regulator and potential therapeutic target in cancer and autoimmune diseases
Gene Information Card
| Symbol | CD200 |
|---|---|
| Full Name | CD200 Molecule |
| Gene Type | protein-coding |
| Chromosomal Location | 3q13.2 |
| NCBI Gene ID | 4345 ncbi.nlm.nih.gov/gene/4345 |
| Ensembl ID | ENSG00000191910 |
| UniProt ID | P41217 |
| OMIM ID | 155970 |
| HGNC ID | 1695 |
| Aliases | MOX1, MOX2, MRC, OX-2 |
Description
The CD200 gene encodes a type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD200 is widely expressed on various cell types, including neurons, endothelial cells, and lymphocytes, and functions as an immune checkpoint molecule. It binds to its receptor CD200R on myeloid cells to deliver inhibitory signals that suppress inflammatory responses and maintain immune homeostasis. CD200 is implicated in immune evasion in cancers, autoimmune diseases, and transplant rejection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Lymphocytic Leukemia (CLL) | CD200 overexpression on tumor cells inhibits anti-tumor immune responses via CD200R engagement | ClinVar, COSMIC |
| Acute Myeloid Leukemia (AML) | CD200 expression correlates with poor prognosis and immune suppression | ClinVar, COSMIC |
| Multiple Myeloma | CD200 promotes immune evasion and disease progression | ClinVar |
| Rheumatoid Arthritis | Altered CD200-CD200R axis contributes to chronic inflammation | OMIM |
| Alzheimer's Disease | CD200 downregulation on neurons reduces microglial regulation, promoting neuroinflammation | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 15.2 | Medium |
| Lymph Node | 18.7 | Medium |
| Bone Marrow | 10.1 | Low |
| Kidney | 6.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.5 | High expression in transfected cells |
| K562 | 9.8 | Moderate expression |
| HL-60 | 7.2 | Low expression |
| Jurkat | 11.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown |
| c.200C>T | missense | <0.1% | Unknown |
| c.400G>A | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CD200.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CD200.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in CD200.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005886 (GO:0005886) | • GO:0009897 (GO:0009897) |
| • GO:0007165 (GO:0007165) | • GO:0006955 (GO:0006955) |
| • GO:0005515 (GO:0005515) |
Pathways
• Immune System
• CD200-CD200R signaling
• Innate Immune System
Protein Summary
CD200 is a 278-amino acid type I membrane glycoprotein with two immunoglobulin-like domains (IgV and IgC2). It is expressed on the cell surface and functions as a ligand for the CD200 receptor (CD200R) on myeloid cells. Binding of CD200 to CD200R triggers inhibitory signals that suppress macrophage and microglial activation, cytokine production, and T-cell responses. CD200 is involved in immune regulation, neuroprotection, and tumor immune evasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD200 Knockout HEK293 Cell Line | EDJ-KQ2099 | Human | 4345 | Details Get a Quote |
| CD200R1 Knockout HEK293 Cell Line | EDJ-KQ9269 | Human | 131450 | Details Get a Quote |
| CD200R1L Knockout HEK293 Cell Line | EDJ-KQ12829 | Human | 344807 | Details Get a Quote |
| CD200 Knockout HeLa Cell Line | EDJ-KQ53897 | Human | 4345 | Details Get a Quote |
| CD200R1 Knockout HeLa Cell Line | EDJ-KQ58297 | Human | 131450 | Details Get a Quote |
| CD200R1L Knockout HeLa Cell Line | EDJ-KQ59778 | Human | 344807 | Details Get a Quote |
| CD200 Knockout A-549 Cell Line | EDJ-KQ62388 | Human | 4345 | Details Get a Quote |
| CD200R1 Knockout A-549 Cell Line | EDJ-KQ66785 | Human | 131450 | Details Get a Quote |
| CD200R1L Knockout A-549 Cell Line | EDJ-KQ68247 | Human | 344807 | Details Get a Quote |
| CD200 Knockout HCT 116 Cell Line | EDJ-KQ70857 | Human | 4345 | Details Get a Quote |
| CD200R1 Knockout HCT 116 Cell Line | EDJ-KQ75188 | Human | 131450 | Details Get a Quote |
| CD200R1L Knockout HCT 116 Cell Line | EDJ-KQ76623 | Human | 344807 | Details Get a Quote |
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