CD163L1 Gene
Scavenger Receptor Cysteine-Rich Type 1 Protein M160
Gene Information Card
| Symbol | CD163L1 |
|---|---|
| Full Name | CD163 molecule-like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 283316 ncbi.nlm.nih.gov/gene/283316 |
| Ensembl ID | ENSG00000177694 |
| UniProt ID | Q9NRR6 |
| OMIM ID | 612376 |
| HGNC ID | 26441 |
| Aliases | M160, SCART1, CD163B, dJ561O2.1 |
Description
CD163L1 (CD163 molecule-like 1) is a protein-coding gene that encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. The encoded protein is a type I transmembrane protein expressed primarily in macrophages and dendritic cells. It functions as a receptor for bacteria and may play a role in the innate immune response. CD163L1 is also known as M160 and is closely related to CD163.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | Altered expression may modulate macrophage-mediated inflammation | PMID: 23455675 |
| Atherosclerosis | Potential role in lipid scavenging and foam cell formation | PMID: 25231987 |
| Bacterial infections | Receptor for Gram-positive and Gram-negative bacteria | PMID: 16940120 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Bone marrow | 15.2 | Medium |
| Small intestine | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 18.0 | Differentiated macrophages show higher expression |
| U937 (histiocytic lymphoma) | 14.5 | Induced by PMA |
| HepG2 (hepatocellular carcinoma) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional effect |
| c.567delA (p.Glu189fs) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.567delA) likely result in truncated protein and loss of scavenger receptor activity.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • scavenger receptor activity (GO:0005044) | • protein binding (GO:0005515) |
| • plasma membrane (GO:0005886) | • innate immune response (GO:0045087) |
| • receptor-mediated endocytosis (GO:0006898) |
Pathways
• Scavenger receptor pathway
• Innate immune system (Reactome: R-HSA-168249)
Protein Summary
The CD163L1 protein (M160) is a 130 kDa type I transmembrane glycoprotein containing 12 scavenger receptor cysteine-rich (SRCR) domains. It is expressed on the surface of macrophages and dendritic cells. The protein binds to bacteria and facilitates their uptake, contributing to host defense. It also participates in the clearance of hemoglobin-haptoglobin complexes, similar to CD163.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD163L1 Knockout HEK293 Cell Line | EDJ-KQ12826 | Human | 283316 | Details Get a Quote |
| CD163L1 Knockout HeLa Cell Line | EDJ-KQ41967 | Human | 283316 | Details Get a Quote |
| CD163L1 Knockout HCT 116 Cell Line | EDJ-KQ40719 | Human | 283316 | Details Get a Quote |
| CD163L1 Knockout A-549 Cell Line | EDJ-KQ67854 | Human | 283316 | Details Get a Quote |
