CD101 Gene - Cluster of Differentiation 101
A transmembrane glycoprotein involved in immune regulation and T-cell activation.
Gene Information Card
| Symbol | CD101 |
|---|---|
| Full Name | Cluster of Differentiation 101 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.1 |
| NCBI Gene ID | 9398 ncbi.nlm.nih.gov/gene/9398 |
| Ensembl ID | ENSG00000134242 |
| UniProt ID | Q93033 |
| OMIM ID | 604542 |
| HGNC ID | 1690 |
| Aliases | V7, IGSF2, P126 |
Description
CD101 (Cluster of Differentiation 101) is a protein-coding gene located on chromosome 1p13.1. It encodes a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD101 is expressed primarily on activated T cells, monocytes, and dendritic cells, and plays a role in immune regulation, T-cell activation, and costimulation. The gene has been implicated in inflammatory and autoimmune conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | CD101 expression on synovial T cells may modulate inflammatory responses. | PMID: 11590182 |
| Inflammatory Bowel Disease | Altered CD101 expression on intestinal T cells linked to chronic inflammation. | PMID: 14608356 |
| HIV Infection | CD101 expression on CD4+ T cells correlates with disease progression. | PMID: 15356147 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Blood | 8.2 | Low |
| Bone marrow | 6.1 | Low |
| Lung | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.0 | High expression |
| THP-1 (monocytic leukemia) | 9.5 | Moderate expression |
| HEK293 (embryonic kidney) | 0.5 | Very low expression |
| HeLa (cervical carcinoma) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.01% | p.Pro412Ser; unknown functional impact |
| c.56_57del | frameshift deletion | <0.001% | p.Leu19Argfs*5; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift deletions (e.g., c.56_57del) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported in CD101.
Dominant Negative (DN)
No dominant-negative mutations have been described for CD101.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • cell surface receptor signaling pathway (GO:0007166) |
| • T cell activation (GO:0042110) | • protein binding (GO:0005515) |
Pathways
• T cell receptor signaling pathway (Reactome: R-HSA-202403)
• Costimulation by the CD28 family (Reactome: R-HSA-388841)
Protein Summary
The CD101 protein is a 126 kDa type I transmembrane glycoprotein with seven extracellular immunoglobulin-like domains. It is expressed on activated T cells, monocytes, and dendritic cells. CD101 functions as a costimulatory molecule, modulating T-cell receptor signaling and cytokine production. Its expression is upregulated during inflammation and may serve as a marker for certain T-cell subsets.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD101 Knockout HEK293 Cell Line | EDJ-KQ6585 | Human | 9398 | Details Get a Quote |
| CD101 Knockout HCT 116 Cell Line | EDJ-KQ30807 | Human | 9398 | Details Get a Quote |
| CD101 Knockout HeLa Cell Line | EDJ-KQ55153 | Human | 9398 | Details Get a Quote |
| CD101 Knockout A-549 Cell Line | EDJ-KQ63633 | Human | 9398 | Details Get a Quote |
