CCRL2: C-C Motif Chemokine Receptor Like 2
Atypical chemokine receptor involved in inflammation, immune regulation, and cancer progression.
Gene Information Card
| Symbol | CCRL2 |
|---|---|
| Full Name | C-C motif chemokine receptor like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 9034 ncbi.nlm.nih.gov/gene/9034 |
| Ensembl ID | ENSG00000163823 |
| UniProt ID | P51685 |
| OMIM ID | 602939 |
| HGNC ID | 1612 |
| Aliases | ACKR5, CKRX, CRAM-A, CRAM-B, HCR |
Description
CCRL2 (C-C motif chemokine receptor like 2) is an atypical chemokine receptor that belongs to the G protein-coupled receptor family. Unlike classical chemokine receptors, CCRL2 does not couple to G proteins and is involved in chemokine scavenging, cell migration, and immune modulation. It is expressed on immune cells, endothelial cells, and various tissues, playing roles in inflammation, tumor microenvironment, and infectious diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory diseases | CCRL2 modulates chemokine gradients, affecting leukocyte recruitment and inflammation resolution. | PMID: 25246658 |
| Cancer (e.g., breast, lung) | CCRL2 expression in tumor-associated macrophages and endothelial cells promotes angiogenesis and metastasis. | PMID: 28476875 |
| Asthma | CCRL2 variants associated with altered chemokine signaling in airway inflammation. | PMID: 22922876 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lymph node | 7.1 | Medium |
| Bone marrow | 6.4 | Low |
| Blood | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | High expression |
| HUVEC (endothelial) | 9.8 | Moderate expression |
| A549 (lung cancer) | 4.1 | Low expression |
| MCF7 (breast cancer) | 3.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown functional impact |
| c.487G>A (p.Val163Met) | Missense | <0.01% | Potential altered ligand binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • chemokine receptor activity |
| • cell surface receptor signaling pathway | • inflammatory response |
| • immune response |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
CCRL2 is a 7-transmembrane domain receptor that lacks G protein coupling. It binds chemokines such as CCL19 and chemerin, acting as a scavenger or presenting ligand to other receptors. The protein is involved in dendritic cell migration, macrophage polarization, and tumor angiogenesis. Its expression is regulated by inflammatory stimuli and hypoxia.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCRL2 Knockout HEK293 Cell Line | EDJ-KQ6438 | Human | 9034 | Details Get a Quote |
| CCRL2 Knockout HeLa Cell Line | EDJ-KQ55061 | Human | 9034 | Details Get a Quote |
| CCRL2 Knockout A-549 Cell Line | EDJ-KQ63541 | Human | 9034 | Details Get a Quote |
| CCRL2 Knockout HCT 116 Cell Line | EDJ-KQ72011 | Human | 9034 | Details Get a Quote |
