CCR7: C-C Motif Chemokine Receptor 7
A key regulator of immune cell trafficking and lymph node homing
Gene Information Card
| Symbol | CCR7 |
|---|---|
| Full Name | C-C Motif Chemokine Receptor 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 1236 ncbi.nlm.nih.gov/gene/1236 |
| Ensembl ID | ENSG00000126353 |
| UniProt ID | P32248 |
| OMIM ID | 600242 |
| HGNC ID | 1608 |
| Aliases | CD197, CDw197, CMKBR7, EBI1, CC-CKR-7, CCR-7, BLR2 |
Description
CCR7 (C-C Motif Chemokine Receptor 7) is a G protein-coupled receptor for chemokines CCL19 and CCL21. It is expressed on various immune cells, including naive and central memory T cells, B cells, and mature dendritic cells. CCR7 directs cell migration to secondary lymphoid organs, playing a critical role in immune surveillance, tolerance, and adaptive immune responses. Dysregulation of CCR7 is implicated in cancer metastasis, inflammatory diseases, and immune disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CCR7 overexpression promotes lymph node metastasis via CCL19/CCL21 signaling | PMID: 15626780, COSMIC |
| Non-small cell lung cancer | CCR7 upregulation correlates with lymph node metastasis and poor prognosis | PMID: 19137028 |
| Gastric cancer | CCR7 expression associated with lymphatic invasion and metastasis | PMID: 15911239 |
| HIV-1 infection | CCR7 acts as a coreceptor for HIV-1 entry into CD4+ T cells | PMID: 9396756 |
| Immunodeficiency (WHIM syndrome-like) | CCR7 loss-of-function mutations impair lymphocyte trafficking | ClinVar, OMIM #600242 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 10.2 | High |
| Appendix | 8.7 | High |
| Bone marrow | 6.1 | Medium |
| Lung | 2.3 | Low |
| Breast | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.3 | High expression |
| Raji (Burkitt lymphoma) | 12.8 | High expression |
| MCF7 (breast cancer) | 4.2 | Moderate expression |
| A549 (lung cancer) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 0.8 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.748C>T (p.Arg250*) | Nonsense | <0.01% | Loss of function; truncated protein |
| c.1010G>A (p.Arg337Gln) | Missense | <0.01% | Impaired ligand binding and signaling |
| c.1123C>T (p.Arg375Trp) | Missense | <0.01% | Reduced cell surface expression |
| c.1267_1268insA (p.Thr423Asnfs*5) | Frameshift | <0.01% | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg250*, p.Thr423Asnfs*5) lead to truncated or non-functional CCR7, impairing lymphocyte homing and immune response.
Gain of Function (GOF)
Not well documented; some missense variants may enhance signaling but are rare.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in CCR7.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• T cell receptor signaling pathway (KEGG: hsa04660)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
CCR7 is a 378-amino acid G protein-coupled receptor with seven transmembrane domains. It binds chemokines CCL19 and CCL21, activating downstream pathways such as PI3K/Akt and MAPK, leading to cytoskeletal rearrangement and chemotaxis. The receptor is essential for dendritic cell and lymphocyte migration to lymph nodes, and its expression is tightly regulated during immune responses. Post-translational modifications include N-glycosylation and phosphorylation, which modulate receptor trafficking and signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCR7 Knockout HEK293 Cell Line | EDJ-KQ1367 | Human | 1236 | Details Get a Quote |
| CCR7 Knockout A-549 Cell Line | EDJ-KQ22154 | Human | 1236 | Details Get a Quote |
| CCR7 Knockout HeLa Cell Line | EDJ-KQ52935 | Human | 1236 | Details Get a Quote |
| CCR7 Knockout HCT 116 Cell Line | EDJ-KQ69897 | Human | 1236 | Details Get a Quote |
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