CCR6 Gene - C-C Motif Chemokine Receptor 6
Key regulator of immune cell trafficking and inflammatory responses
Gene Information Card
| Symbol | CCR6 |
|---|---|
| Full Name | C-C motif chemokine receptor 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 1235 ncbi.nlm.nih.gov/gene/1235 |
| Ensembl ID | ENSG00000112414 |
| UniProt ID | P51684 |
| OMIM ID | 601835 |
| HGNC ID | 1607 |
| Aliases | BN-1, CKR-L3, CMKBR6, GPR29, STRL22 |
Description
CCR6 (C-C motif chemokine receptor 6) is a G protein-coupled receptor that specifically binds the chemokine CCL20. It is expressed on various immune cells, including dendritic cells, memory T cells, and B cells, and plays a critical role in immune cell trafficking, lymphoid organ development, and inflammatory responses. CCR6 is involved in the pathogenesis of autoimmune diseases, infectious diseases, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | CCR6-CCL20 axis mediates recruitment of Th17 cells to intestinal mucosa, promoting chronic inflammation | PMID: 22158542 |
| Rheumatoid Arthritis | CCR6+ Th17 cells infiltrate synovial tissue, driving joint inflammation and bone erosion | PMID: 20467446 |
| Psoriasis | CCR6 expression on skin-homing T cells facilitates CCL20-mediated migration to epidermis | PMID: 17632512 |
| Colorectal Cancer | CCR6 signaling promotes tumor cell proliferation, migration, and metastasis via PI3K/AKT pathway | PMID: 25362209 |
| HIV-1 Infection | CCR6 acts as a co-receptor for HIV-1 entry in certain T cell subsets | PMID: 15331735 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 10.2 | High |
| Appendix | 8.7 | Medium |
| Bone marrow | 6.3 | Medium |
| Lung | 3.1 | Low |
| Skin | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T cell leukemia) | 15.4 | High expression |
| THP-1 (monocytic leukemia) | 9.8 | Moderate expression |
| Raji (Burkitt lymphoma) | 7.2 | Moderate expression |
| HEK293 (embryonic kidney) | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | 0.02% | Reduced ligand binding affinity |
| c.487G>A (p.Gly163Arg) | missense | 0.01% | Altered receptor trafficking |
| c.893A>G (p.Asn298Ser) | missense | 0.03% | Impaired signaling |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Thr34Met reduce CCL20 binding and downstream signaling, impairing immune cell chemotaxis.
Gain of Function (GOF)
Not well documented; some variants may enhance receptor activity but require further validation.
Dominant Negative (DN)
No dominant-negative mutations reported for CCR6.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • C-C chemokine receptor activity |
| • C-C chemokine binding | • cell surface receptor signaling pathway |
| • chemokine-mediated signaling pathway | • positive regulation of cytosolic calcium ion concentration |
| • immune response | • cell chemotaxis |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Th17 cell differentiation (KEGG: hsa04659)
Protein Summary
CCR6 is a 374-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated exclusively by CCL20, leading to intracellular calcium mobilization, MAPK/ERK activation, and PI3K/AKT signaling. The receptor is essential for the homing of dendritic cells and memory T cells to mucosal tissues and skin. Its expression is tightly regulated in immune homeostasis and dysregulated in inflammatory and malignant conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCR6 Knockout HEK293 Cell Line | EDJ-KQ50201 | Human | 1235 | Details Get a Quote |
| CCR6 Knockout HeLa Cell Line | EDJ-KQ52934 | Human | 1235 | Details Get a Quote |
| CCR6 Knockout A-549 Cell Line | EDJ-KQ61402 | Human | 1235 | Details Get a Quote |
| CCR6 Knockout HCT 116 Cell Line | EDJ-KQ69896 | Human | 1235 | Details Get a Quote |
| CCR6 Knockout Hep-G2 Cell Line | EDC07758 | Human | 1235 | Details Get a Quote |
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