CCR3 Gene (C-C Motif Chemokine Receptor 3)
A key chemokine receptor in eosinophil migration and allergic inflammation
Gene Information Card
| Symbol | CCR3 |
|---|---|
| Full Name | C-C motif chemokine receptor 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 1232 ncbi.nlm.nih.gov/gene/1232 |
| Ensembl ID | ENSG00000183625 |
| UniProt ID | P51677 |
| OMIM ID | 601268 |
| HGNC ID | 1606 |
| Aliases | CC-CKR-3, CMKBR3, CKR3, CD193 |
Description
CCR3 (C-C motif chemokine receptor 3) is a G protein-coupled receptor for CC chemokines such as eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), and RANTES (CCL5). It is predominantly expressed on eosinophils, basophils, mast cells, and Th2 lymphocytes, playing a central role in allergic inflammation, eosinophil recruitment, and asthma pathogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CCR3 mediates eosinophil and Th2 cell chemotaxis to airway epithelium, promoting inflammation and airway hyperresponsiveness. | PMID: 10837024, ClinVar |
| Eosinophilic Esophagitis | CCR3 overexpression on eosinophils drives esophageal infiltration via eotaxin-3 signaling. | PMID: 17381626, ClinVar |
| Allergic Rhinitis | CCR3 activation recruits eosinophils to nasal mucosa, contributing to symptoms. | PMID: 10469313 |
| Hypereosinophilic Syndrome | CCR3 variants may alter receptor activity, influencing eosinophil accumulation. | PMID: 16940118, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole blood | 0.8 | Low |
| Lung | 2.1 | Medium |
| Spleen | 1.5 | Low |
| Bone marrow | 1.2 | Low |
| Small intestine | 0.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Eosinophils (primary) | 12.5 | High expression |
| Th2 lymphocytes (primary) | 8.3 | Moderate expression |
| Mast cells (HMC-1) | 6.7 | Moderate expression |
| Basophils (primary) | 10.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.824C>T (p.Thr275Met) | Missense | <0.01% | Reduced ligand binding affinity (loss of function) |
| c.101G>A (p.Arg34His) | Missense | <0.01% | Altered receptor internalization |
| c.1-?_*_?del | Deletion | Rare | Complete loss of function (null allele) |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Thr275Met) reduce chemokine binding and signaling, impairing eosinophil chemotaxis.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CCR3.
Dominant Negative (DN)
Not described for CCR3.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • C-C chemokine receptor activity |
| • chemokine receptor activity | • signal transduction |
| • cell chemotaxis | • inflammatory response |
| • immune response | • eosinophil chemotaxis |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Asthma (KEGG: hsa05310)
• Allograft rejection (KEGG: hsa05330)
Protein Summary
CCR3 is a 355-amino acid seven-transmembrane G protein-coupled receptor. Upon ligand binding (e.g., eotaxin), it activates Gi/o proteins, leading to calcium mobilization, actin polymerization, and chemotaxis. It is a key therapeutic target for eosinophilic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCR3 Knockout HEK293 Cell Line | EDJ-KQ4298 | Human | 1232 | Details Get a Quote |
| CCR3 Knockout HCT 116 Cell Line | EDJ-KQ26788 | Human | 1232 | Details Get a Quote |
| CCR3 Knockout HeLa Cell Line | EDJ-KQ52931 | Human | 1232 | Details Get a Quote |
| CCR3 Knockout A-549 Cell Line | EDJ-KQ61399 | Human | 1232 | Details Get a Quote |
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