CCR10 Gene (C-C Motif Chemokine Receptor 10)
A chemokine receptor involved in immune cell trafficking and implicated in inflammatory diseases and cancer.
Gene Information Card
| Symbol | CCR10 |
|---|---|
| Full Name | C-C motif chemokine receptor 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 2826 ncbi.nlm.nih.gov/gene/2826 |
| Ensembl ID | ENSG00000161570 |
| UniProt ID | P46092 |
| OMIM ID | 600240 |
| HGNC ID | 1607 |
| Aliases | GPR2, CC-CKR-10, CKR10 |
Description
CCR10 (C-C motif chemokine receptor 10) is a G protein-coupled receptor for chemokines CCL27 and CCL28. It plays a key role in the homing of memory T lymphocytes to the skin and mucosal tissues, and is involved in inflammatory responses and cancer metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | CCR10-mediated recruitment of lymphocytes to intestinal mucosa; dysregulation contributes to chronic inflammation | PMID: 20628061 |
| Melanoma | CCR10 expression on melanoma cells promotes metastasis to skin via CCL27 ligand | PMID: 15601829 |
| Atopic Dermatitis | CCR10+ T cells are recruited to skin lesions, driving Th2-type inflammation | PMID: 15210937 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 0.0 | Not detected |
| Lymph node | 0.0 | Not detected |
| Spleen | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | No endogenous expression |
| Jurkat | 0.0 | No endogenous expression |
| K562 | 0.0 | No endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T | missense | <0.01% | p.Arg34Cys; unknown functional impact |
| c.200G>A | missense | <0.01% | p.Arg67His; unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in major databases.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • C-C chemokine receptor activity |
| • C-C chemokine binding | • cell surface receptor signaling pathway |
| • chemokine-mediated signaling pathway | • positive regulation of cytosolic calcium ion concentration |
| • cell chemotaxis | • lymphocyte chemotaxis |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
CCR10 is a 362-amino acid protein with seven transmembrane domains typical of chemokine receptors. It is expressed on a subset of memory T cells, particularly those homing to skin and mucosal tissues. The receptor binds CCL27 and CCL28, mediating chemotaxis and cell adhesion. CCR10 is implicated in inflammatory skin diseases and certain cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCR10 Knockout HEK293 Cell Line | EDJ-KQ3228 | Human | 2826 | Details Get a Quote |
| CCR10 Knockout HeLa Cell Line | EDJ-KQ24736 | Human | 2826 | Details Get a Quote |
| CCR10 Knockout A-549 Cell Line | EDJ-KQ61860 | Human | 2826 | Details Get a Quote |
| CCR10 Knockout HCT 116 Cell Line | EDJ-KQ70342 | Human | 2826 | Details Get a Quote |
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