CCR1 Gene - C-C Motif Chemokine Receptor 1
CCR1: A key chemokine receptor in inflammation, immune regulation, and cancer progression
Gene Information Card
| Symbol | CCR1 |
|---|---|
| Full Name | C-C motif chemokine receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 1230 ncbi.nlm.nih.gov/gene/1230 |
| Ensembl ID | ENSG00000163823 |
| UniProt ID | P32246 |
| OMIM ID | 601159 |
| HGNC ID | 1605 |
| Aliases | CKR1, CMKBR1, HM145, MIP1aR, CD191 |
Description
CCR1 (C-C motif chemokine receptor 1) is a G protein-coupled receptor for several C-C chemokines, including CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), and CCL23 (MPIF-1). It mediates chemotaxis of monocytes, neutrophils, and lymphocytes, playing a critical role in inflammation, immune response, and cancer metastasis. The gene is located on chromosome 3p21.31 and is expressed in multiple immune and non-immune tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | CCR1 overexpression on synovial macrophages promotes inflammatory cell recruitment and joint destruction | PMID: 10852717 |
| Multiple Sclerosis | CCR1+ T cells and monocytes infiltrate CNS lesions; ligand CCL3 is elevated in CSF | PMID: 10651994 |
| Prostate Cancer | CCR1 signaling via CCL3 promotes bone metastasis and tumor growth | PMID: 19244118 |
| HIV-1 Infection | CCR1 acts as a minor co-receptor for HIV-1 entry | PMID: 8649512 |
| Atherosclerosis | CCR1 mediates monocyte recruitment to arterial plaques | PMID: 10899915 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.3 | Medium |
| Spleen | 8.7 | Medium |
| Lung | 6.5 | Low |
| Whole Blood | 5.2 | Low |
| Lymph Node | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | High expression |
| HL-60 (promyeloblast) | 10.1 | Moderate expression |
| K-562 (erythroleukemia) | 3.4 | Low expression |
| HeLa (cervical carcinoma) | 1.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | 0.0002 (gnomAD) | Unknown functional effect |
| c.200G>A (p.Arg67His) | missense | 0.0001 (gnomAD) | Unknown functional effect |
| c.303_305del (p.Phe101del) | in-frame deletion | Rare | Potential loss of ligand binding |
Mutation functional classification
Loss of Function (LOF)
Deletions in the extracellular N-terminus or transmembrane domains may impair ligand binding and receptor activation.
Gain of Function (GOF)
Not well documented; some missense variants may enhance signaling but require further validation.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported for CCR1.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • C-C chemokine receptor activity |
| • chemokine binding | • cell surface receptor signaling pathway |
| • chemotaxis | • inflammatory response |
| • immune response | • calcium ion transport |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
CCR1 is a 355-amino acid G protein-coupled receptor with seven transmembrane domains. It is expressed on the surface of monocytes, macrophages, neutrophils, and T lymphocytes. Upon binding chemokines such as CCL3 and CCL5, CCR1 activates intracellular signaling cascades including PI3K/Akt, MAPK, and calcium mobilization, leading to cell migration, adhesion, and degranulation. The receptor is a target for therapeutic intervention in inflammatory diseases and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCR10 Knockout HEK293 Cell Line | EDJ-KQ3228 | Human | 2826 | Details Get a Quote |
| CCR1 Knockout HEK293 Cell Line | EDJ-KQ4300 | Human | 1230 | Details Get a Quote |
| CCR10 Knockout HeLa Cell Line | EDJ-KQ24736 | Human | 2826 | Details Get a Quote |
| CCR1 Knockout HeLa Cell Line | EDJ-KQ52930 | Human | 1230 | Details Get a Quote |
| CCR1 Knockout A-549 Cell Line | EDJ-KQ61398 | Human | 1230 | Details Get a Quote |
| CCR10 Knockout A-549 Cell Line | EDJ-KQ61860 | Human | 2826 | Details Get a Quote |
| CCR1 Knockout HCT 116 Cell Line | EDJ-KQ69893 | Human | 1230 | Details Get a Quote |
| CCR10 Knockout HCT 116 Cell Line | EDJ-KQ70342 | Human | 2826 | Details Get a Quote |
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