CCNYL1: Cyclin Y Like 1
A cyclin family member with potential roles in cell cycle regulation and cancer
Gene Information Card
| Symbol | CCNYL1 |
|---|---|
| Full Name | Cyclin Y Like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 151195 ncbi.nlm.nih.gov/gene/151195 |
| Ensembl ID | ENSG00000163002 |
| UniProt ID | Q8N7R7 |
| OMIM ID | 612543 |
| HGNC ID | 23377 |
| Aliases | C2orf54, cyclin-Y-like-1 |
Description
CCNYL1 (Cyclin Y Like 1) is a protein-coding gene belonging to the cyclin family. Cyclins are key regulators of the cell cycle, and CCNYL1 is thought to play a role in cell cycle progression and may be involved in cancer development. The gene is located on chromosome 2q33.1 and encodes a protein of 341 amino acids. Expression data suggest broad tissue distribution with highest levels in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential role in cell cycle dysregulation; overexpression observed in some tumors | COSMIC, literature |
| Testicular germ cell tumors | High expression in testis; possible involvement in spermatogenesis and tumorigenesis | NCBI Gene, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 4.8 | Low |
| Lung | 3.1 | Low |
| Liver | 2.5 | Low |
| Kidney | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.5 | Embryonic kidney; moderate expression |
| HeLa | 8.3 | Cervical cancer; moderate expression |
| K562 | 6.7 | Leukemia; moderate expression |
| A549 | 4.2 | Lung cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Trp) | Missense | <0.1% | Unknown; rare variant |
| c.456G>A (p.Val152Met) | Missense | <0.1% | Unknown; rare variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • cyclin-dependent protein serine/threonine kinase regulator activity | • cell cycle |
| • mitotic cell cycle | • nucleus |
| • cytoplasm |
Pathways
• Cell Cycle
• Cyclin D associated events in G1
Protein Summary
The CCNYL1 protein (UniProt Q8N7R7) is a 341-amino-acid cyclin that contains a cyclin box domain. It is predicted to regulate cyclin-dependent kinases (CDKs) and may influence cell cycle progression. Expression is highest in testis, suggesting a role in spermatogenesis. The protein is localized to both nucleus and cytoplasm.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNYL1 Knockout HEK293 Cell Line | EDJ-KQ11322 | Human | 151195 | Details Get a Quote |
| CCNYL1B Knockout HEK293 Cell Line | EDJ-KQ12825 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout A-549 Cell Line | EDJ-KQ41963 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout HCT 116 Cell Line | EDJ-KQ41964 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout HeLa Cell Line | EDJ-KQ41965 | Human | 102724485 | Details Get a Quote |
| CCNYL1 Knockout A-549 Cell Line | EDJ-KQ39470 | Human | 151195 | Details Get a Quote |
| CCNYL1 Knockout HCT 116 Cell Line | EDJ-KQ39471 | Human | 151195 | Details Get a Quote |
| CCNYL1 Knockout HeLa Cell Line | EDJ-KQ39472 | Human | 151195 | Details Get a Quote |
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