CCNG2
Cyclin G2: A Cell Cycle Regulator and Tumor Suppressor
Gene Information Card
| Symbol | CCNG2 |
|---|---|
| Full Name | Cyclin G2 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.1 |
| NCBI Gene ID | 901 ncbi.nlm.nih.gov/gene/901 |
| Ensembl ID | ENSG00000138764 |
| UniProt ID | Q16589 |
| OMIM ID | 603203 |
| HGNC ID | 1592 |
| Aliases | cyclin G2, CCNG2 |
Description
CCNG2 encodes cyclin G2, a member of the cyclin family involved in cell cycle regulation. It acts as a negative regulator of cell proliferation and is implicated in tumor suppression. Expression is induced by DNA damage and growth inhibitory signals, and it interacts with CDK2 and other cell cycle components.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Downregulation of CCNG2 promotes cell proliferation and tumor growth; acts as a tumor suppressor | PMID: 23454728 |
| Hepatocellular carcinoma | Reduced expression correlates with poor prognosis; inhibits cell cycle progression | PMID: 25636874 |
| Gastric cancer | CCNG2 hypermethylation leads to silencing and increased tumorigenesis | PMID: 24158429 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Spleen | 8.7 | Medium |
| Lung | 5.2 | Low |
| Breast | 3.1 | Low |
| Liver | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 4.5 | Reduced expression compared to normal |
| HepG2 (liver cancer) | 3.2 | Low expression |
| A549 (lung cancer) | 2.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of function; start codon loss |
| c.325C>T (p.Arg109Trp) | Missense | <0.1% | Unknown significance |
| c.487G>A (p.Gly163Ser) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations leading to truncated protein; reduced expression in tumors
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cell cycle (GO:0007049) | • protein kinase binding (GO:0019901) |
| • regulation of cell cycle (GO:0051726) |
Pathways
• Cell cycle (KEGG hsa04110)
• p53 signaling pathway (KEGG hsa04115)
Protein Summary
Cyclin G2 is a 344-amino acid protein with a cyclin N-terminal domain. It localizes to the nucleus and interacts with CDK2 and other proteins to regulate cell cycle progression. It is induced by DNA damage and growth arrest signals, and its loss is associated with various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNG2 Knockout HEK293 Cell Line | EDJ-KQ1534 | Human | 901 | Details Get a Quote |
| CCNG2 Knockout A-549 Cell Line | EDJ-KQ21190 | Human | 901 | Details Get a Quote |
| CCNG2 Knockout HCT 116 Cell Line | EDJ-KQ21191 | Human | 901 | Details Get a Quote |
| CCNG2 Knockout HeLa Cell Line | EDJ-KQ21192 | Human | 901 | Details Get a Quote |
