CCNG1 (Cyclin G1)
A cyclin involved in cell cycle regulation and DNA damage response
Gene Information Card
| Symbol | CCNG1 |
|---|---|
| Full Name | Cyclin G1 |
| Gene Type | Protein-coding |
| Chromosomal Location | 5q32 |
| NCBI Gene ID | 900 ncbi.nlm.nih.gov/gene/900 |
| Ensembl ID | ENSG00000113368 |
| UniProt ID | P51959 |
| OMIM ID | 601578 |
| HGNC ID | 1591 |
| Aliases | CYCG1, cyclin-G1 |
Description
CCNG1 encodes cyclin G1, a member of the cyclin family involved in cell cycle regulation. It is a transcriptional target of the tumor suppressor p53 and plays a role in the DNA damage response, apoptosis, and cell cycle arrest. Cyclin G1 interacts with CDK5 and other proteins to modulate cell proliferation and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of CCNG1 may promote tumor growth by dysregulating cell cycle control | PMID: 12368274 |
| Hepatocellular carcinoma | CCNG1 upregulation associated with poor prognosis and increased proliferation | PMID: 25642768 |
| Colorectal cancer | CCNG1 amplification linked to advanced stage and metastasis | PMID: 28411373 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.8 | Low |
| Brain | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical cancer cell line |
| MCF7 | 10.2 | Breast cancer cell line |
| HepG2 | 8.7 | Liver cancer cell line |
| A549 | 7.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown significance |
| c.200C>T | Nonsense | <0.1% | Predicted loss of function |
| c.350G>A | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.200C>T) are predicted to cause loss of function by introducing a premature stop codon.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • cyclin-dependent protein serine/threonine kinase regulator activity | • protein binding |
| • cell cycle | • G1/S transition of mitotic cell cycle |
| • DNA damage response | • apoptotic process |
Pathways
• p53 signaling pathway
• Cell cycle
• DNA damage response
Protein Summary
Cyclin G1 is a 295-amino acid protein with a cyclin N-terminal domain. It localizes to the nucleus and cytoplasm, and its expression is induced by p53 in response to DNA damage. Cyclin G1 can interact with CDK5 and the B' subunit of protein phosphatase 2A, modulating cell cycle progression and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNG1 Knockout HEK293 Cell Line | EDJ-KQ3523 | Human | 900 | Details Get a Quote |
| CCNG1 Knockout A-549 Cell Line | EDJ-KQ26677 | Human | 900 | Details Get a Quote |
| CCNG1 Knockout HCT 116 Cell Line | EDJ-KQ26679 | Human | 900 | Details Get a Quote |
| CCNG1 Knockout HeLa Cell Line | EDJ-KQ26680 | Human | 900 | Details Get a Quote |
