CCNB3
Cyclin B3: A Regulator of Cell Cycle and Spermatogenesis
Gene Information Card
| Symbol | CCNB3 |
|---|---|
| Full Name | Cyclin B3 |
| Gene Type | Protein coding |
| Chromosomal Location | Xp11.22 |
| NCBI Gene ID | 85417 ncbi.nlm.nih.gov/gene/85417 |
| Ensembl ID | ENSG00000147010 |
| UniProt ID | Q8WWL7 |
| OMIM ID | 300456 |
| HGNC ID | 1592 |
| Aliases | CYCB3, cyclin-B3 |
Description
CCNB3 encodes cyclin B3, a member of the cyclin family involved in cell cycle regulation. Cyclin B3 binds to and activates cyclin-dependent kinase 2 (CDK2) and is essential for meiotic progression during spermatogenesis. It is predominantly expressed in testis and plays a critical role in male fertility.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Testicular germ cell tumors | CCNB3 overexpression may drive proliferation via CDK2 activation | PMID: 25670082 |
| Spermatogenic failure | Loss-of-function variants impair meiotic cell cycle | PMID: 31589614 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 0.8 | Low |
| Bone marrow | 0.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (testicular embryonal carcinoma) | 15.2 | High expression |
| HeLa (cervical carcinoma) | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34*) | Nonsense | Rare | Premature truncation, loss of function |
| c.457G>A (p.Gly153Arg) | Missense | Rare | Potential disruption of cyclin fold |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants leading to truncated protein or nonsense-mediated decay.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • cyclin-dependent protein serine/threonine kinase regulator activity | • cell cycle |
| • mitotic cell cycle | • meiotic cell cycle |
| • spermatogenesis |
Pathways
• Cell Cycle
• Oocyte meiosis
Protein Summary
Cyclin B3 is a 1395-amino acid protein containing a cyclin N-terminal domain and a cyclin C-terminal domain. It localizes to the nucleus and interacts with CDK2 to regulate G2/M transition and meiotic progression. Expression is largely restricted to testis, with lower levels in other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNB3 Knockout HEK293 Cell Line | EDJ-KQ1533 | Human | 85417 | Details Get a Quote |
| CCNB3 Knockout A-549 Cell Line | EDJ-KQ21188 | Human | 85417 | Details Get a Quote |
| CCNB3 Knockout HCT 116 Cell Line | EDJ-KQ21189 | Human | 85417 | Details Get a Quote |
| CCNB3 Knockout HeLa Cell Line | EDJ-KQ57711 | Human | 85417 | Details Get a Quote |
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